Items where Subject is "Subjects > Nutrition"
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2026
Article
Subjects > Psychology
Subjects > Nutrition Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Universidad Internacional do Cuanza > Research > Articles and books Abierto Inglés Background: Mild Cognitive Impairment (MCI) is viewed as a transitional stage between normal brain aging and dementia and is characterized by subtle cognitive deficits without significant impairment in daily functioning. Growing evidence supports the contribution of neuroinflammation and modifiable lifestyle factors, including diet, in the progression of cognitive decline.Aim: This study aimed to investigate the association between adherence to the Mediterranean diet, neuroinflammatory biomarkers, and MCI status in older adults.Design: Ninety-two participants were enrolled in this cross-sectional study, including 37 subjects with MCI. Dietary intake was assessed using a validated food frequency questionnaire (FFQ) and adherence to the Mediterranean diet explored through the MedDietScore. Plasma levels of TGF-β1 and TNF-α were measured by ELISA. Cognitive status was evaluated using the Mini Mental Examination (MMSE) and the Montreal Cognitive Assessment (MoCA), both adjusted for age and education. Statistical analyses included non-parametric tests, correlation analysis, and logistic regression models.Results: MCI patients showed significantly reduced plasma levels of TGF-β1 and increased TNF-α concentrations compared to other participants. After adjustment for potential confounding factors, greater adherence to the Mediterranean diet was associated with a lower likelihood of MCI in a dose–response manner (highest versus lowest adherence quartile, odds ratio: 0.07, 95% confidence interval: 0.01–0.60). Additional adjustment for inflammatory biomarkers attenuated the associations, suggesting a potential mediating role.Conclusion: Our findings showed that higher adherence to Mediterranean diet is associated with lower likelihood of being MCI. Such a relation might be, at least in part, mediated by inflammatory biomarkers. Overall, these results support the role of dietary modulation in preventive strategies against cognitive decline and progression into MCI. Grasso, Margherita and L’Episcopo, Francesca and Fidilio, Annamaria and Olvera-Moreira, Marco Antonio and Toscano, Giuseppe and Muratore, Stefano and Drago, Margherita and Musso, Sabrina and Bentivegna, Veronica and Costanzo, Lucrezia and Toral-Noristz, Melannie and Zambrano-Villacres, Raynier and León Brizuela, Lisandra and Lanza, Giuseppe and Ferri, Raffaele and Caraci, Filippo UNSPECIFIED
Subjects > Nutrition Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Universidad Internacional do Cuanza > Research > Articles and books Abierto Inglés Background: Mild Cognitive Impairment (MCI) is viewed as a transitional stage between normal brain aging and dementia and is characterized by subtle cognitive deficits without significant impairment in daily functioning. Growing evidence supports the contribution of neuroinflammation and modifiable lifestyle factors, including diet, in the progression of cognitive decline.Aim: This study aimed to investigate the association between adherence to the Mediterranean diet, neuroinflammatory biomarkers, and MCI status in older adults.Design: Ninety-two participants were enrolled in this cross-sectional study, including 37 subjects with MCI. Dietary intake was assessed using a validated food frequency questionnaire (FFQ) and adherence to the Mediterranean diet explored through the MedDietScore. Plasma levels of TGF-β1 and TNF-α were measured by ELISA. Cognitive status was evaluated using the Mini Mental Examination (MMSE) and the Montreal Cognitive Assessment (MoCA), both adjusted for age and education. Statistical analyses included non-parametric tests, correlation analysis, and logistic regression models.Results: MCI patients showed significantly reduced plasma levels of TGF-β1 and increased TNF-α concentrations compared to other participants. After adjustment for potential confounding factors, greater adherence to the Mediterranean diet was associated with a lower likelihood of MCI in a dose–response manner (highest versus lowest adherence quartile, odds ratio: 0.07, 95% confidence interval: 0.01–0.60). Additional adjustment for inflammatory biomarkers attenuated the associations, suggesting a potential mediating role.Conclusion: Our findings showed that higher adherence to Mediterranean diet is associated with lower likelihood of being MCI. Such a relation might be, at least in part, mediated by inflammatory biomarkers. Overall, these results support the role of dietary modulation in preventive strategies against cognitive decline and progression into MCI. Grasso, Margherita and L’Episcopo, Francesca and Fidilio, Annamaria and Olvera-Moreira, Marco Antonio and Toscano, Giuseppe and Muratore, Stefano and Drago, Margherita and Musso, Sabrina and Bentivegna, Veronica and Costanzo, Lucrezia and Toral-Noristz, Melannie and Zambrano-Villacres, Raynier and León Brizuela, Lisandra and Lanza, Giuseppe and Ferri, Raffaele and Caraci, Filippo UNSPECIFIED
Adherence to the Mediterranean diet, inflammatory biomarkers and cognitive status in older Italian adults.
Article
Subjects > Nutrition
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Universidad Internacional do Cuanza > Research > Articles and books Abierto Inglés Background: Emerging evidence suggests that there might be an association between excess consumption of ultra-processed foods (UPFs) on cognitive health. UPF intake could promote systemic inflammation, oxidative stress phenomena, and metabolic dysregulation, contributing to neurodegeneration onset and cognitive decline in elderly population.Aim: The aim of this cross-sectional study was to examine the relation between UPF dietary pattern on MCI status in elderly patients taking into account the contribution of inflammatory markers.Design: The dietary intake was assessed using a validated food frequency questionnaire in ninety-two participants. All reported food items were categorized according to the NOVA system, classifying foods on the basis of the extent and purpose of industrial processing. Plasmatic concentrations of TGF-β1 and TNF-ɑ were measured by ELISA assay at the time of baseline neuropsychological evaluation. The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were administered to evaluate the cognitive function in all participants. Non-parametric tests, correlation analysis, and logistic regression models were performed to assess the relations between variables of interest.Results: No significant associations were observed for unprocessed/minimally processed foods, culinary processed foods, or processed foods across the different regression models. In contrast, higher consumption of UPF was associated with increased odds of MCI (adjusted OR = 4.24, 95% CI: 1.05–17.13). However, after additional adjustment for inflammatory biomarkers (TGF-β and TNF-α), the association was attenuated and no longer statistically significant (OR = 4.79, 95% CI: 0.73–31.24), although the direction of the association remained positive.Conclusion: UPF consumption may be associated with increased likelihood of MCI, and inflammatory status may potentially play a role in this association. Grasso, Margherita and L’Episcopo, Francesca and Olvera-Moreira, Marco Antonio and Toscano, Giuseppe and Muratore, Stefano and Tripodi, Maria Angela and Musso, Sabrina and Bentivegna, Veronica and Costanzo, Lucrezia and Fatati, Giusi and Toral-Noristz, Melannie and Zambrano-Villacres, Raynier and León Brizuela, Lisandra and Ferri, Raffaele and Lanza, Giuseppe and Caraci, Filippo UNSPECIFIED
Ibero-american International University > Research > Articles and books
Universidad Internacional do Cuanza > Research > Articles and books Abierto Inglés Background: Emerging evidence suggests that there might be an association between excess consumption of ultra-processed foods (UPFs) on cognitive health. UPF intake could promote systemic inflammation, oxidative stress phenomena, and metabolic dysregulation, contributing to neurodegeneration onset and cognitive decline in elderly population.Aim: The aim of this cross-sectional study was to examine the relation between UPF dietary pattern on MCI status in elderly patients taking into account the contribution of inflammatory markers.Design: The dietary intake was assessed using a validated food frequency questionnaire in ninety-two participants. All reported food items were categorized according to the NOVA system, classifying foods on the basis of the extent and purpose of industrial processing. Plasmatic concentrations of TGF-β1 and TNF-ɑ were measured by ELISA assay at the time of baseline neuropsychological evaluation. The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were administered to evaluate the cognitive function in all participants. Non-parametric tests, correlation analysis, and logistic regression models were performed to assess the relations between variables of interest.Results: No significant associations were observed for unprocessed/minimally processed foods, culinary processed foods, or processed foods across the different regression models. In contrast, higher consumption of UPF was associated with increased odds of MCI (adjusted OR = 4.24, 95% CI: 1.05–17.13). However, after additional adjustment for inflammatory biomarkers (TGF-β and TNF-α), the association was attenuated and no longer statistically significant (OR = 4.79, 95% CI: 0.73–31.24), although the direction of the association remained positive.Conclusion: UPF consumption may be associated with increased likelihood of MCI, and inflammatory status may potentially play a role in this association. Grasso, Margherita and L’Episcopo, Francesca and Olvera-Moreira, Marco Antonio and Toscano, Giuseppe and Muratore, Stefano and Tripodi, Maria Angela and Musso, Sabrina and Bentivegna, Veronica and Costanzo, Lucrezia and Fatati, Giusi and Toral-Noristz, Melannie and Zambrano-Villacres, Raynier and León Brizuela, Lisandra and Ferri, Raffaele and Lanza, Giuseppe and Caraci, Filippo UNSPECIFIED
Consumption of ultra-processed foods is associated with cognitive status in elderly patients.
Article
Subjects > Nutrition
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Articles and books Abierto Inglés Fish is widely promoted as part of healthy dietary patterns. The aim of this review was to summarise current literature on the environmental footprint of fish and its role within sustainable diets. Fish generally represents a minor share of total dietary environmental impacts, contributing to a smaller proportion of greenhouse-gas emissions (GHGe), land and water use than meat and other animal products. Several modelling studies showed that substituting meat with fish or increasing fish intake within optimised dietary patterns can reduce environmental impacts, although the magnitude varies by country, diet type, and fish species. However, some analyses reported increased GHGe associated with higher fish intake, especially in models ensuring nutritional quality. Overall, fish consumption is compatible with achieving nutritionally adequate and lower environmental impacts, although optimal match between environmental boundaries and nutritional needs is not always possible. These findings suggest that fish can play a constructive role in sustainable diets when integrated thoughtfully within broader dietary shifts. Dolci, Alberto and Scuderi, Alessandro and Frias-Toral, Evelyn and Hernández Cruz, Leonardo de Jesús and Di Mauro, Andrea and Furnari, Fabrizio and Rosi, Alice and Scazzina, Francesca and Grosso, Giuseppe UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, leonardo.hernandez@unib.org, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Articles and books Abierto Inglés Fish is widely promoted as part of healthy dietary patterns. The aim of this review was to summarise current literature on the environmental footprint of fish and its role within sustainable diets. Fish generally represents a minor share of total dietary environmental impacts, contributing to a smaller proportion of greenhouse-gas emissions (GHGe), land and water use than meat and other animal products. Several modelling studies showed that substituting meat with fish or increasing fish intake within optimised dietary patterns can reduce environmental impacts, although the magnitude varies by country, diet type, and fish species. However, some analyses reported increased GHGe associated with higher fish intake, especially in models ensuring nutritional quality. Overall, fish consumption is compatible with achieving nutritionally adequate and lower environmental impacts, although optimal match between environmental boundaries and nutritional needs is not always possible. These findings suggest that fish can play a constructive role in sustainable diets when integrated thoughtfully within broader dietary shifts. Dolci, Alberto and Scuderi, Alessandro and Frias-Toral, Evelyn and Hernández Cruz, Leonardo de Jesús and Di Mauro, Andrea and Furnari, Fabrizio and Rosi, Alice and Scazzina, Francesca and Grosso, Giuseppe UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, leonardo.hernandez@unib.org, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED
Environmental burden of fish in healthy and sustainable diets.
2025
Article
Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Articles and books
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Universidad Internacional do Cuanza > Research > Articles and books
University of La Romana > Research > Scientific Production Abierto Inglés Fasting–feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal timing underscores the importance of maintaining circadian alignment in order to avoid creating a metabolic environment conducive to carcinogenesis following the molecular and systemic disruption of metabolic performance and immune function. The chronicity of such a condition may support the initiation and progression of cancer through a variety of mechanisms, including increased oxidative stress, immune suppression, and the activation of proliferative signaling pathways. This review aims to summarize current evidence from human studies and provide an overview of the potential mechanisms underscoring the role of chrononutrition (including time-restricted eating) on cancer risk. Current evidence shows that the morning chronotype, suggesting an alignment between physiological circadian rhythms and eating timing, is associated with a lower risk of cancer. Also, early time-restricted eating and prolonged nighttime fasting were also associated with a lower risk of cancer. The current evidence suggests that the chronotype influences cancer risk through cell cycle regulation, the modulation of metabolic pathways and inflammation, and gut microbiota fluctuations. In conclusion, although there are no clear guidelines on this matter, emerging evidence supports the hypothesis that the role of time-related eating (i.e., time/calorie-restricted feeding and intermittent/periodic fasting) could potentially lead to a reduced risk of cancer. Godos, Justyna and Currenti, Walter and Ferri, Raffaele and Lanza, Giuseppe and Caraci, Filippo and Frias-Toral, Evelyn and Guglielmetti, Monica and Ferraris, Cinzia and Lipari, Vivian and Carvajal Altamiranda, Stefanía and Galvano, Fabio and Castellano, Sabrina and Grosso, Giuseppe UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, vivian.lipari@uneatlantico.es, stefania.carvajal@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED
Subjects > Nutrition Europe University of Atlantic > Research > Articles and books
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Universidad Internacional do Cuanza > Research > Articles and books
University of La Romana > Research > Scientific Production Abierto Inglés Fasting–feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal timing underscores the importance of maintaining circadian alignment in order to avoid creating a metabolic environment conducive to carcinogenesis following the molecular and systemic disruption of metabolic performance and immune function. The chronicity of such a condition may support the initiation and progression of cancer through a variety of mechanisms, including increased oxidative stress, immune suppression, and the activation of proliferative signaling pathways. This review aims to summarize current evidence from human studies and provide an overview of the potential mechanisms underscoring the role of chrononutrition (including time-restricted eating) on cancer risk. Current evidence shows that the morning chronotype, suggesting an alignment between physiological circadian rhythms and eating timing, is associated with a lower risk of cancer. Also, early time-restricted eating and prolonged nighttime fasting were also associated with a lower risk of cancer. The current evidence suggests that the chronotype influences cancer risk through cell cycle regulation, the modulation of metabolic pathways and inflammation, and gut microbiota fluctuations. In conclusion, although there are no clear guidelines on this matter, emerging evidence supports the hypothesis that the role of time-related eating (i.e., time/calorie-restricted feeding and intermittent/periodic fasting) could potentially lead to a reduced risk of cancer. Godos, Justyna and Currenti, Walter and Ferri, Raffaele and Lanza, Giuseppe and Caraci, Filippo and Frias-Toral, Evelyn and Guglielmetti, Monica and Ferraris, Cinzia and Lipari, Vivian and Carvajal Altamiranda, Stefanía and Galvano, Fabio and Castellano, Sabrina and Grosso, Giuseppe UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, vivian.lipari@uneatlantico.es, stefania.carvajal@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED
Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies.
Article
Subjects > Nutrition
Europe University of Atlantic > Research > Articles and books
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Articles and books
University of La Romana > Research > Scientific Production Abierto Inglés Mango is one of the most beloved fruits and plays an indispensable role in the agricultural economies of many tropical countries like Pakistan, India, and other Southeast Asian countries. Similar to other fruits, mango cultivation is also threatened by various diseases, including Anthracnose and Red Rust. Although farmers try to mitigate such situations on time, early and accurate detection of mango diseases remains challenging due to multiple factors, such as limited understanding of disease diversity, similarity in symptoms, and frequent misclassification. To avoid such instances, this study proposes a multimodal deep learning framework that leverages both leaf and fruit images to improve classification performance and generalization. Individual CNN-based pre-trained models, including ResNet-50, MobileNetV2, EfficientNet-B0, and ConvNeXt, were trained separately on curated datasets of mango leaf and fruit diseases. A novel Modality Attention Fusion (MAF) mechanism was introduced to dynamically weight and combine predictions from both modalities based on their discriminative strength, as some diseases are more prominent on leaves than on fruits, and vice versa. To address overfitting and improve generalization, a class-aware augmentation pipeline was integrated, which performs augmentation according to the specific characteristics of each class. The proposed attention-based fusion strategy significantly outperformed individual models and static fusion approaches, achieving a test accuracy of 99.08%, an F1 score of 99.03%, and a perfect ROC-AUC of 99.96% using EfficientNet-B0 as the base. To evaluate the model’s real-world applicability, an interactive web application was developed using the Django framework and evaluated through out-of-distribution (OOD) testing on diverse mango samples collected from public sources. These findings underline the importance of combining visual cues from multiple organs of plants and adapting model attention to contextual features for real-world agricultural diagnostics. Mohsin, Muhammad and Hashmi, Muhammad Shadab Alam and Delgado Noya, Irene and Garay, Helena and Abdel Samee, Nagwan and Ashraf, Imran UNSPECIFIED, UNSPECIFIED, irene.delgado@uneatlantico.es, helena.garay@uneatlantico.es, UNSPECIFIED, UNSPECIFIED
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Articles and books
University of La Romana > Research > Scientific Production Abierto Inglés Mango is one of the most beloved fruits and plays an indispensable role in the agricultural economies of many tropical countries like Pakistan, India, and other Southeast Asian countries. Similar to other fruits, mango cultivation is also threatened by various diseases, including Anthracnose and Red Rust. Although farmers try to mitigate such situations on time, early and accurate detection of mango diseases remains challenging due to multiple factors, such as limited understanding of disease diversity, similarity in symptoms, and frequent misclassification. To avoid such instances, this study proposes a multimodal deep learning framework that leverages both leaf and fruit images to improve classification performance and generalization. Individual CNN-based pre-trained models, including ResNet-50, MobileNetV2, EfficientNet-B0, and ConvNeXt, were trained separately on curated datasets of mango leaf and fruit diseases. A novel Modality Attention Fusion (MAF) mechanism was introduced to dynamically weight and combine predictions from both modalities based on their discriminative strength, as some diseases are more prominent on leaves than on fruits, and vice versa. To address overfitting and improve generalization, a class-aware augmentation pipeline was integrated, which performs augmentation according to the specific characteristics of each class. The proposed attention-based fusion strategy significantly outperformed individual models and static fusion approaches, achieving a test accuracy of 99.08%, an F1 score of 99.03%, and a perfect ROC-AUC of 99.96% using EfficientNet-B0 as the base. To evaluate the model’s real-world applicability, an interactive web application was developed using the Django framework and evaluated through out-of-distribution (OOD) testing on diverse mango samples collected from public sources. These findings underline the importance of combining visual cues from multiple organs of plants and adapting model attention to contextual features for real-world agricultural diagnostics. Mohsin, Muhammad and Hashmi, Muhammad Shadab Alam and Delgado Noya, Irene and Garay, Helena and Abdel Samee, Nagwan and Ashraf, Imran UNSPECIFIED, UNSPECIFIED, irene.delgado@uneatlantico.es, helena.garay@uneatlantico.es, UNSPECIFIED, UNSPECIFIED
Dual-modality fusion for mango disease classification using dynamic attention based ensemble of leaf & fruit images.
Article
Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Articles and books
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Universidad Internacional do Cuanza > Research > Articles and books
University of La Romana > Research > Scientific Production Abierto Inglés Maize is a staple crop worldwide, essential for food security, livestock feed, and industrial uses. Its health directly impacts agricultural productivity and economic stability. Effective detection of maize crop health is crucial for preventing disease spread and ensuring high yields. This study presents VG-GNBNet, an innovative transfer learning model that accurately detects healthy and infected maize crops through a two-step feature extraction process. The proposed model begins by leveraging the visual geometry group (VGG-16) network to extract initial pixel-based spatial features from the crop images. These features are then further refined using the Gaussian Naive Bayes (GNB) model and feature decomposition-based matrix factorization mechanism, which generates more informative features for classification purposes. This study incorporates machine learning models to ensure a comprehensive evaluation. By comparing VG-GNBNet's performance against these models, we validate its robustness and accuracy. Integrating deep learning and machine learning techniques allows VG-GNBNet to capitalize on the strengths of both approaches, leading to superior performance. Extensive experiments demonstrate that the proposed VG-GNBNet+GNB model significantly outperforms other models, achieving an impressive accuracy score of 99.85%. This high accuracy highlights the model's potential for practical application in the agricultural sector, where the precise detection of crop health is crucial for effective disease management and yield optimization. Tanveer, Muhammad Usama and Munir, Kashif and Raza, Ali and Abualigah, Laith and Garay, Helena and Prado González, Luis Eduardo and Ashraf, Imran UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, helena.garay@uneatlantico.es, uis.prado@uneatlantico.es, UNSPECIFIED
Subjects > Nutrition Europe University of Atlantic > Research > Articles and books
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Universidad Internacional do Cuanza > Research > Articles and books
University of La Romana > Research > Scientific Production Abierto Inglés Maize is a staple crop worldwide, essential for food security, livestock feed, and industrial uses. Its health directly impacts agricultural productivity and economic stability. Effective detection of maize crop health is crucial for preventing disease spread and ensuring high yields. This study presents VG-GNBNet, an innovative transfer learning model that accurately detects healthy and infected maize crops through a two-step feature extraction process. The proposed model begins by leveraging the visual geometry group (VGG-16) network to extract initial pixel-based spatial features from the crop images. These features are then further refined using the Gaussian Naive Bayes (GNB) model and feature decomposition-based matrix factorization mechanism, which generates more informative features for classification purposes. This study incorporates machine learning models to ensure a comprehensive evaluation. By comparing VG-GNBNet's performance against these models, we validate its robustness and accuracy. Integrating deep learning and machine learning techniques allows VG-GNBNet to capitalize on the strengths of both approaches, leading to superior performance. Extensive experiments demonstrate that the proposed VG-GNBNet+GNB model significantly outperforms other models, achieving an impressive accuracy score of 99.85%. This high accuracy highlights the model's potential for practical application in the agricultural sector, where the precise detection of crop health is crucial for effective disease management and yield optimization. Tanveer, Muhammad Usama and Munir, Kashif and Raza, Ali and Abualigah, Laith and Garay, Helena and Prado González, Luis Eduardo and Ashraf, Imran UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, helena.garay@uneatlantico.es, uis.prado@uneatlantico.es, UNSPECIFIED
Novel Transfer Learning Approach for Detecting Infected and Healthy Maize Crop Using Leaf Images.
Other
Subjects > Nutrition
Europe University of Atlantic > Research > Software
Fundación Universitaria Internacional de Colombia > Research > Software
Ibero-american International University > Research > Software
Ibero-american International University > Research > ICT Tools
Universidad Internacional do Cuanza > Research > Software
University of La Romana > Research > Software Abierto Inglés, Español, Portugués Se trata de una plataforma que integra cinco bots diferentes disponibles en cinco idiomas. El bot enseña al estudiante de nutrición y dietética a realizar un proceso de exploración clínica de forma online/interactiva. Estos bots proporcionan los siguientes casos: Gastroenterología, Diabetes mellitus tipo 1, enfermedades cardiovasculares y diabetes, obesidad y enfermedades renales. Cada bot dispone de un cuestionario relacionado con el ámbito de la nutrición, y una encuesta final para conocer la experiencia del usuario. Desarrollada en el marco del proyecto E+DIETing_LAB UNSPECIFIED UNSPECIFIED
Fundación Universitaria Internacional de Colombia > Research > Software
Ibero-american International University > Research > Software
Ibero-american International University > Research > ICT Tools
Universidad Internacional do Cuanza > Research > Software
University of La Romana > Research > Software Abierto Inglés, Español, Portugués Se trata de una plataforma que integra cinco bots diferentes disponibles en cinco idiomas. El bot enseña al estudiante de nutrición y dietética a realizar un proceso de exploración clínica de forma online/interactiva. Estos bots proporcionan los siguientes casos: Gastroenterología, Diabetes mellitus tipo 1, enfermedades cardiovasculares y diabetes, obesidad y enfermedades renales. Cada bot dispone de un cuestionario relacionado con el ámbito de la nutrición, y una encuesta final para conocer la experiencia del usuario. Desarrollada en el marco del proyecto E+DIETing_LAB UNSPECIFIED UNSPECIFIED
Virtual Patient (E+DIETing_LAB).
Other
Subjects > Nutrition
Europe University of Atlantic > Research > Software
Fundación Universitaria Internacional de Colombia > Research > Software
Ibero-american International University > Research > Software
Ibero-american International University > Research > ICT Tools
Universidad Internacional do Cuanza > Research > Software
University of La Romana > Research > Software Abierto Inglés, Español, Portugués Una herramienta que ofrece una formación centrada en el Proceso de Atención Nutricional (PAN) y el servicio a la comunidad. Mediante videollamada las personas interesadas pueden recibir consejo dietético gratuito y unas recomendaciones de cómo mejorar su alimentación, bajo la supervisión de un profesor. Desarrollada en el marco del proyecto E+DIETing_LAB UNSPECIFIED UNSPECIFIED
Fundación Universitaria Internacional de Colombia > Research > Software
Ibero-american International University > Research > Software
Ibero-american International University > Research > ICT Tools
Universidad Internacional do Cuanza > Research > Software
University of La Romana > Research > Software Abierto Inglés, Español, Portugués Una herramienta que ofrece una formación centrada en el Proceso de Atención Nutricional (PAN) y el servicio a la comunidad. Mediante videollamada las personas interesadas pueden recibir consejo dietético gratuito y unas recomendaciones de cómo mejorar su alimentación, bajo la supervisión de un profesor. Desarrollada en el marco del proyecto E+DIETing_LAB UNSPECIFIED UNSPECIFIED
Virtual nutritional clinic (E+DIETing_LAB).
2024
Article
Subjects > Nutrition
Europe University of Atlantic > Research > Articles and books
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Articles and books Abierto Inglés Much of nutrition research has been conventionally based on the use of simplistic in vitro systems or animal models, which have been extensively employed in an effort to better understand the relationships between diet and complex diseases as well as to evaluate food safety. Although these models have undeniably contributed to increase our mechanistic understanding of basic biological processes, they do not adequately model complex human physiopathological phenomena, creating concerns about the translatability to humans. During the last decade, extraordinary advancement in stem cell culturing, three-dimensional cell cultures, sequencing technologies, and computer science has occurred, which has originated a wealth of novel human-based and more physiologically relevant tools. These tools, also known as “new approach methodologies,” which comprise patient-derived organoids, organs-on-chip, multi-omics approach, along with computational models and analysis, represent innovative and exciting tools to forward nutrition research from a human-biology-oriented perspective. After considering some shortcomings of conventional in vitro and vivo approaches, here we describe the main novel available and emerging tools that are appropriate for designing a more human-relevant nutrition research. Our aim is to encourage discussion on the opportunity to explore innovative paths in nutrition research and to promote a paradigm-change toward a more human biology-focused approach to better understand human nutritional pathophysiology, to evaluate novel food products, and to develop more effective targeted preventive or therapeutic strategies while helping in reducing the number and replacing animals employed in nutrition research. Cassotta, Manuela and Cianciosi, Danila and Elexpuru Zabaleta, Maria and Elío Pascual, Iñaki and Sumalla Cano, Sandra and Giampieri, Francesca and Battino, Maurizio manucassotta@gmail.com, UNSPECIFIED, maria.elexpuru@uneatlantico.es, inaki.elio@uneatlantico.es, sandra.sumalla@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Articles and books Abierto Inglés Much of nutrition research has been conventionally based on the use of simplistic in vitro systems or animal models, which have been extensively employed in an effort to better understand the relationships between diet and complex diseases as well as to evaluate food safety. Although these models have undeniably contributed to increase our mechanistic understanding of basic biological processes, they do not adequately model complex human physiopathological phenomena, creating concerns about the translatability to humans. During the last decade, extraordinary advancement in stem cell culturing, three-dimensional cell cultures, sequencing technologies, and computer science has occurred, which has originated a wealth of novel human-based and more physiologically relevant tools. These tools, also known as “new approach methodologies,” which comprise patient-derived organoids, organs-on-chip, multi-omics approach, along with computational models and analysis, represent innovative and exciting tools to forward nutrition research from a human-biology-oriented perspective. After considering some shortcomings of conventional in vitro and vivo approaches, here we describe the main novel available and emerging tools that are appropriate for designing a more human-relevant nutrition research. Our aim is to encourage discussion on the opportunity to explore innovative paths in nutrition research and to promote a paradigm-change toward a more human biology-focused approach to better understand human nutritional pathophysiology, to evaluate novel food products, and to develop more effective targeted preventive or therapeutic strategies while helping in reducing the number and replacing animals employed in nutrition research. Cassotta, Manuela and Cianciosi, Danila and Elexpuru Zabaleta, Maria and Elío Pascual, Iñaki and Sumalla Cano, Sandra and Giampieri, Francesca and Battino, Maurizio manucassotta@gmail.com, UNSPECIFIED, maria.elexpuru@uneatlantico.es, inaki.elio@uneatlantico.es, sandra.sumalla@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es
Human‐based new approach methodologies to accelerate advances in nutrition research.
Article
Subjects > Nutrition
Europe University of Atlantic > Research > Articles and books
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
University of La Romana > Research > Scientific Production Abierto Inglés Background/Objectives: The diet quality of younger individuals is decreasing globally, with alarming trends also in the Mediterranean region. The aim of this study was to assess diet quality and adequacy in relation to country-specific dietary recommendations for children and adolescents living in the Mediterranean area. Methods: A cross-sectional survey was conducted of 2011 parents of the target population participating in the DELICIOUS EU-PRIMA project. Dietary data and cross-references with food-based recommendations and the application of the youth healthy eating index (YHEI) was assessed through 24 h recalls and food frequency questionnaires. Results: Adherence to recommendations on plant-based foods was low (less than ∼20%), including fruit and vegetables adequacy in all countries, legume adequacy in all countries except for Italy, and cereal adequacy in all countries except for Portugal. For animal products and dietary fats, the adequacy in relation to the national food-based dietary recommendations was slightly better (∼40% on average) in most countries, although the Eastern countries reported worse rates. Higher scores on the YHEI predicted adequacy in relation to vegetables (except Egypt), fruit (except Lebanon), cereals (except Spain), and legumes (except Spain) in most countries. Younger children (p < 0.005) reporting having 8–10 h adequate sleep duration (p < 0.001), <2 h/day screen time (p < 0.001), and a medium/high physical activity level (p < 0.001) displayed a better diet quality. Moreover, older respondents (p < 0.001) with a medium/high educational level (p = 0.001) and living with a partner (p = 0.003) reported that their children had a better diet quality. Conclusions: Plant-based food groups, including fruit, vegetables, legumes, and even (whole-grain) cereals are underrepresented in the diets of Mediterranean children and adolescents. Moreover, the adequate consumption of other important dietary components, such as milk and dairy products, is rather disregarded, leading to substantially suboptimal diets and poor adequacy in relation to dietary guidelines. Giampieri, Francesca and Rosi, Alice and Scazzina, Francesca and Frias-Toral, Evelyn and Abdelkarim, Osama and Aly, Mohamed and Zambrano-Villacres, Raynier and Pons, Juancho and Vázquez-Araújo, Laura and Sumalla Cano, Sandra and Elío Pascual, Iñaki and Monasta, Lorenzo and Mata, Ana and Pardo, María Isabel and Busó, Pablo and Grosso, Giuseppe francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
University of La Romana > Research > Scientific Production Abierto Inglés Background/Objectives: The diet quality of younger individuals is decreasing globally, with alarming trends also in the Mediterranean region. The aim of this study was to assess diet quality and adequacy in relation to country-specific dietary recommendations for children and adolescents living in the Mediterranean area. Methods: A cross-sectional survey was conducted of 2011 parents of the target population participating in the DELICIOUS EU-PRIMA project. Dietary data and cross-references with food-based recommendations and the application of the youth healthy eating index (YHEI) was assessed through 24 h recalls and food frequency questionnaires. Results: Adherence to recommendations on plant-based foods was low (less than ∼20%), including fruit and vegetables adequacy in all countries, legume adequacy in all countries except for Italy, and cereal adequacy in all countries except for Portugal. For animal products and dietary fats, the adequacy in relation to the national food-based dietary recommendations was slightly better (∼40% on average) in most countries, although the Eastern countries reported worse rates. Higher scores on the YHEI predicted adequacy in relation to vegetables (except Egypt), fruit (except Lebanon), cereals (except Spain), and legumes (except Spain) in most countries. Younger children (p < 0.005) reporting having 8–10 h adequate sleep duration (p < 0.001), <2 h/day screen time (p < 0.001), and a medium/high physical activity level (p < 0.001) displayed a better diet quality. Moreover, older respondents (p < 0.001) with a medium/high educational level (p = 0.001) and living with a partner (p = 0.003) reported that their children had a better diet quality. Conclusions: Plant-based food groups, including fruit, vegetables, legumes, and even (whole-grain) cereals are underrepresented in the diets of Mediterranean children and adolescents. Moreover, the adequate consumption of other important dietary components, such as milk and dairy products, is rather disregarded, leading to substantially suboptimal diets and poor adequacy in relation to dietary guidelines. Giampieri, Francesca and Rosi, Alice and Scazzina, Francesca and Frias-Toral, Evelyn and Abdelkarim, Osama and Aly, Mohamed and Zambrano-Villacres, Raynier and Pons, Juancho and Vázquez-Araújo, Laura and Sumalla Cano, Sandra and Elío Pascual, Iñaki and Monasta, Lorenzo and Mata, Ana and Pardo, María Isabel and Busó, Pablo and Grosso, Giuseppe francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED
Youth Healthy Eating Index (YHEI) and Diet Adequacy in Relation to Country-Specific National Dietary Recommendations in Children and Adolescents in Five Mediterranean Countries from the DELICIOUS Project.
2023
Article
Subjects > Nutrition
Europe University of Atlantic > Research > Articles and books
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books Cerrado Inglés Diets enriched in plant-based foods are associated with the maintenance of a good well-being and with the prevention of many non-communicable diseases. The health effects of fruits and vegetables consumption are mainly due to the presence of micronutrients, including vitamins and minerals, and polyphenols, plant secondary metabolites. One of the most important classes of phenolic compounds are anthocyanins, that confer the typical purple-red color to many foods, such as berries, peaches, plums, red onions, purple corn, eggplants, as well as purple carrots, sweet potatoes and red cabbages, among others. This commentary aims to briefly highlight the progress made by science in the last years, focusing on some unexpected aspects related with anthocyanins, such as their bioavailability, their health effects and their relationship with gut microbiota Giampieri, Francesca and Cianciosi, Danila and Alvarez-Suarez, José M. and Quiles, José L. and Forbes-Hernández, Tamara Y. and Navarro-Hortal, María D. and Machì, Michele and Pali-Casanova, Ramón and Martínez Espinosa, Julio César and Chen, Xiumin and Zhang, Di and Bai, Weibin and Lingmin, Tian and Mezzetti, Bruno and Battino, Maurizio and Diaz, Yasmany Armas francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, jose.quiles@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, ramon.pali@unini.edu.mx, ulio.martinez@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books Cerrado Inglés Diets enriched in plant-based foods are associated with the maintenance of a good well-being and with the prevention of many non-communicable diseases. The health effects of fruits and vegetables consumption are mainly due to the presence of micronutrients, including vitamins and minerals, and polyphenols, plant secondary metabolites. One of the most important classes of phenolic compounds are anthocyanins, that confer the typical purple-red color to many foods, such as berries, peaches, plums, red onions, purple corn, eggplants, as well as purple carrots, sweet potatoes and red cabbages, among others. This commentary aims to briefly highlight the progress made by science in the last years, focusing on some unexpected aspects related with anthocyanins, such as their bioavailability, their health effects and their relationship with gut microbiota Giampieri, Francesca and Cianciosi, Danila and Alvarez-Suarez, José M. and Quiles, José L. and Forbes-Hernández, Tamara Y. and Navarro-Hortal, María D. and Machì, Michele and Pali-Casanova, Ramón and Martínez Espinosa, Julio César and Chen, Xiumin and Zhang, Di and Bai, Weibin and Lingmin, Tian and Mezzetti, Bruno and Battino, Maurizio and Diaz, Yasmany Armas francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, jose.quiles@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, ramon.pali@unini.edu.mx, ulio.martinez@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED
Anthocyanins: what do we know until now?
Article
Subjects > Nutrition
Europe University of Atlantic > Research > Articles and books
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books Cerrado Inglés Betalains are water-soluble, nitrogen-containing vacuolar pigment and can be divided into two subclasses: the yellow – orange betaxanthins and the red – violet betacyanin. These pigments can be found mainly in Latin America, but also in some parts of Asia, Africa, Australia and in the Mediterranean area. In this work an overview related with the status of research about betalains extracted from Opuntia spp and the enforces made to evaluate their positive incidence in the human body is provided. Several studies enhance their anticancer, anti-inflammatory and antioxidant properties. They also exhibit antimicrobial and antidiabetic effect. Taking into account these properties, betalains seem to be a promising natural alternative as a colorant to replace the synthetic ones in the food additive industry. In addition, the use of Opuntia spp fruits as possible colorant sources in the Food Industry, may contribute positively to the sustainable development in semi-arid regions. Armas Diaz, Yasmany and Qi, Zexiu and Yang, Bei and Martínez López, Nohora Milena and Briones Urbano, Mercedes and Cianciosi, Danila UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, UNSPECIFIED
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books Cerrado Inglés Betalains are water-soluble, nitrogen-containing vacuolar pigment and can be divided into two subclasses: the yellow – orange betaxanthins and the red – violet betacyanin. These pigments can be found mainly in Latin America, but also in some parts of Asia, Africa, Australia and in the Mediterranean area. In this work an overview related with the status of research about betalains extracted from Opuntia spp and the enforces made to evaluate their positive incidence in the human body is provided. Several studies enhance their anticancer, anti-inflammatory and antioxidant properties. They also exhibit antimicrobial and antidiabetic effect. Taking into account these properties, betalains seem to be a promising natural alternative as a colorant to replace the synthetic ones in the food additive industry. In addition, the use of Opuntia spp fruits as possible colorant sources in the Food Industry, may contribute positively to the sustainable development in semi-arid regions. Armas Diaz, Yasmany and Qi, Zexiu and Yang, Bei and Martínez López, Nohora Milena and Briones Urbano, Mercedes and Cianciosi, Danila UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, UNSPECIFIED
Betalains: The main bioactive compounds of Opuntia spp and their possible health benefits in the Mediterranean diet.
Article
Subjects > Nutrition
Europe University of Atlantic > Research > Articles and books
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books Abierto Inglés Alpha-linolenic acid (ALA) is a long-chain polyunsaturated essential fatty acid of the Ω3 series found mainly in vegetables, especially in the fatty part of oilseeds, dried fruit, berries, and legumes. It is very popular for its preventive use in several diseases: It seems to reduce the risk of the onset or decrease some phenomena related to inflammation, oxidative stress, and conditions of dysregulation of the immune response. Recent studies have confirmed these unhealthy situations also in patients with severe coronavirus disease 2019 (COVID-19). Different findings (in vitro, in vivo, and clinical ones), summarized and analyzed in this review, have showed an important role of ALA in other various non-COVID physiological and pathological situations against “cytokines storm,” chemokines secretion, oxidative stress, and dysregulation of immune cells that are also involved in the infection of the 2019 novel coronavirus. According to the effects of ALA against all the aforementioned situations (also present in patients with a severe clinical picture of severe acute respiratory syndrome-(CoV-2) infection), there may be the biologic plausibility of a prophylactic effect of this compound against COVID-19 symptoms and fatality. Cianciosi, Danila and Diaz, Yasmany Armas and Gaddi, Antonio Vittorino and Capello, Fabio and Savo, Maria Teresa and Pali-Casanova, Ramón and Martínez Espinosa, Julio César and Pascual Barrera, Alina Eugenia and Navarro‐Hortal, Maria‐Dolores and Tian, Lingmin and Bai, Weibin and Giampieri, Francesca and Battino, Maurizio UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, ramon.pali@unini.edu.mx, ulio.martinez@unini.edu.mx, alina.pascual@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books Abierto Inglés Alpha-linolenic acid (ALA) is a long-chain polyunsaturated essential fatty acid of the Ω3 series found mainly in vegetables, especially in the fatty part of oilseeds, dried fruit, berries, and legumes. It is very popular for its preventive use in several diseases: It seems to reduce the risk of the onset or decrease some phenomena related to inflammation, oxidative stress, and conditions of dysregulation of the immune response. Recent studies have confirmed these unhealthy situations also in patients with severe coronavirus disease 2019 (COVID-19). Different findings (in vitro, in vivo, and clinical ones), summarized and analyzed in this review, have showed an important role of ALA in other various non-COVID physiological and pathological situations against “cytokines storm,” chemokines secretion, oxidative stress, and dysregulation of immune cells that are also involved in the infection of the 2019 novel coronavirus. According to the effects of ALA against all the aforementioned situations (also present in patients with a severe clinical picture of severe acute respiratory syndrome-(CoV-2) infection), there may be the biologic plausibility of a prophylactic effect of this compound against COVID-19 symptoms and fatality. Cianciosi, Danila and Diaz, Yasmany Armas and Gaddi, Antonio Vittorino and Capello, Fabio and Savo, Maria Teresa and Pali-Casanova, Ramón and Martínez Espinosa, Julio César and Pascual Barrera, Alina Eugenia and Navarro‐Hortal, Maria‐Dolores and Tian, Lingmin and Bai, Weibin and Giampieri, Francesca and Battino, Maurizio UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, ramon.pali@unini.edu.mx, ulio.martinez@unini.edu.mx, alina.pascual@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED
Can alpha‐linolenic acid be a modulator of “cytokine storm,” oxidative stress and immune response in SARS‐CoV‐2 infection?
Article
Subjects > Nutrition
Europe University of Atlantic > Research > Articles and books
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books Cerrado Inglés Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-Fluorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluorouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/β-catenin, Hedgehog and Notch pathways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects. Cianciosi, Danila and Armas Diaz, Yasmany and Alvarez-Suarez, José M. and Chen, Xiumin and Zhang, Di and Martínez López, Nohora Milena and Briones Urbano, Mercedes and Quiles, José L. and Amici, Adolfo and Battino, Maurizio and Giampieri, Francesca UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, jose.quiles@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books Cerrado Inglés Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-Fluorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluorouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/β-catenin, Hedgehog and Notch pathways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects. Cianciosi, Danila and Armas Diaz, Yasmany and Alvarez-Suarez, José M. and Chen, Xiumin and Zhang, Di and Martínez López, Nohora Milena and Briones Urbano, Mercedes and Quiles, José L. and Amici, Adolfo and Battino, Maurizio and Giampieri, Francesca UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, jose.quiles@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es
Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal.
2022
Other
Subjects > Nutrition
Europe University of Atlantic > Research > Software
Fundación Universitaria Internacional de Colombia > Research > Software
Ibero-american International University > Research > Software
Ibero-american International University > Research > ICT Tools
Universidad Internacional do Cuanza > Research > Software
University of La Romana > Research > Software Abierto Inglés, Español, Italiano, Portugués Composición Nutricional es un espacio creado para proporcionar una serie de servicios de valor añadido, ofreciendo herramientas, recursos e informaciones sobre programas de formación e investigación para profesionales e interesados en el ámbito de la nutrición y salud. UNSPECIFIED UNSPECIFIED
Fundación Universitaria Internacional de Colombia > Research > Software
Ibero-american International University > Research > Software
Ibero-american International University > Research > ICT Tools
Universidad Internacional do Cuanza > Research > Software
University of La Romana > Research > Software Abierto Inglés, Español, Italiano, Portugués Composición Nutricional es un espacio creado para proporcionar una serie de servicios de valor añadido, ofreciendo herramientas, recursos e informaciones sobre programas de formación e investigación para profesionales e interesados en el ámbito de la nutrición y salud. UNSPECIFIED UNSPECIFIED
Composición Nutricional.
Revista
Subjects > Nutrition
Europe University of Atlantic > Research > Scientific Magazines
Ibero-american International University > Research > Scientific Magazines
Ibero-american International University > Research > Scientific Journals
Universidad Internacional do Cuanza > Research > Scientific Magazines
Fundación Universitaria Internacional de Colombia > Research > Scientific Magazines Abierto Inglés La revista MLS Health and Nutrition Research nace como una publicación semestral con el objetivo de publicar artículos originales de investigación y de revisión tanto en áreas básicas como aplicadas y metodológicas que supongan una contribución científica al progreso de cualquier ámbito de la salud y nutrición como objetivo principal. Los artículos incluidos en esta revista se publican en español, portugués e inglés. La vocación internacional de esta revista promueve la difusión del conocimiento en sus diferentes áreas. UNSPECIFIED mls@devnull.funiber.org
Ibero-american International University > Research > Scientific Magazines
Ibero-american International University > Research > Scientific Journals
Universidad Internacional do Cuanza > Research > Scientific Magazines
Fundación Universitaria Internacional de Colombia > Research > Scientific Magazines Abierto Inglés La revista MLS Health and Nutrition Research nace como una publicación semestral con el objetivo de publicar artículos originales de investigación y de revisión tanto en áreas básicas como aplicadas y metodológicas que supongan una contribución científica al progreso de cualquier ámbito de la salud y nutrición como objetivo principal. Los artículos incluidos en esta revista se publican en español, portugués e inglés. La vocación internacional de esta revista promueve la difusión del conocimiento en sus diferentes áreas. UNSPECIFIED mls@devnull.funiber.org
MLS Health and Nutrition Research.
Article
Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Articles and books
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Articles and books Cerrado Inglés Cactus has been used in traditional folk medicine because of its role in treating a number of diseases and conditions. Prickly pear fruit is an excellent source of secondary metabolites (i.e., betalains, flavonoids, and ascorbic acid) with health-promoting properties against many common human diseases, including diabetes, hypertension, hypercholesterolemia, rheumatic pain, gastric mucosa diseases and asthma. In addition, prickly pears are potential candidates for the development of low-cost functional foods because they grow with low water requirements in arid regions of the world. This review describes the main bioactive compounds found in this fruit and shows the in vitro and some clinical studies about the fruit of most important cactus (Opuntia ficus-indica) and its relationship with some chronic diseases. Even though a lot of effort have been done to study the relationship between this fruit and the human health, more studies on Opuntia ficus-indica could help better understand its pharmacological mechanism of action to provide clear scientific evidence to explain its traditional uses, and to identify its therapeutic potential in other diseases. Armas Diaz, Yasmany and Machì, Michele and Salinari, Alessia and Mazas Pérez-Oleaga, Cristina and Martínez López, Nohora Milena and Briones Urbano, Mercedes and Cianciosi, Danila UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, UNSPECIFIED
Subjects > Nutrition Europe University of Atlantic > Research > Articles and books
Fundación Universitaria Internacional de Colombia > Research > Articles and books
Ibero-american International University > Research > Articles and books
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Articles and books Cerrado Inglés Cactus has been used in traditional folk medicine because of its role in treating a number of diseases and conditions. Prickly pear fruit is an excellent source of secondary metabolites (i.e., betalains, flavonoids, and ascorbic acid) with health-promoting properties against many common human diseases, including diabetes, hypertension, hypercholesterolemia, rheumatic pain, gastric mucosa diseases and asthma. In addition, prickly pears are potential candidates for the development of low-cost functional foods because they grow with low water requirements in arid regions of the world. This review describes the main bioactive compounds found in this fruit and shows the in vitro and some clinical studies about the fruit of most important cactus (Opuntia ficus-indica) and its relationship with some chronic diseases. Even though a lot of effort have been done to study the relationship between this fruit and the human health, more studies on Opuntia ficus-indica could help better understand its pharmacological mechanism of action to provide clear scientific evidence to explain its traditional uses, and to identify its therapeutic potential in other diseases. Armas Diaz, Yasmany and Machì, Michele and Salinari, Alessia and Mazas Pérez-Oleaga, Cristina and Martínez López, Nohora Milena and Briones Urbano, Mercedes and Cianciosi, Danila UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, UNSPECIFIED
Prickly pear fruits from "Opuntia ficus-indica" varieties as a source of potential bioactive compounds in the Mediterranean diet.
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