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Framework to Detect Adulterated Honey Using Hyperspectral Imaging and Machine Learning
Honey is a natural product renowned for its nutritional and medicinal properties. However, the increasing market demand in Pakistan has led to frequent instances of adulterated and fraudulent honey. Conventional detection methods are widely used but are often ineffective in accurately identifying adulteration. This study proposes a novel approach to detecting adulteration in honey, specifically the mixing of sugar, using machine learning (ML) techniques in conjunction with hyperspectral imaging (HSI). By leveraging HSI, we capture distinct spectral features of both pure and adulterated honey. These spectral features are processed and analyzed using ML algorithms trained on a dataset comprising pure and mixed honey samples. Experiments involve binary, as well as, multiclass (5 classes) honey samples with different levels of adulteration. In addition, data balancing is also carried out using synthetic minority oversampling technique (SMOTE). The results prove the proposed approach to be efficient in detecting adulteration across various honey varieties, with linear regression achieved 99.9% while support vector machine and multilayer perceptron obtaining a 98.7% accuracy for binary class. For the multiple classes of honey, the multilayer perceptron shows a 96.67% accuracy outperforming the remaining ML and deep learning models. Among the deep learning models, the convolutional neural network (CNN) achieved the best performance with an accuracy of 94.67% after applying the SMOTE × 3 (three times of over samples of original samples of each class) data balancing strategy, whereas recurrent neural network (RNN), long short-term memory (LSTM), and gated recurrent unit (GRU) models showed comparatively lower performance.
Oral Microbiota, the Oral–Brain Axis, and Neurodegeneration: Mechanisms and Dietary Modulation
The oral microbiota represents a complex and dynamic microbial ecosystem that plays a critical role in preserving both oral and systemic homeostasis. Emerging evidence suggests that alterations in oral microbial milieu (dysbiosis) may contribute to the pathogenesis of neurodegenerative disorders, especially Alzheimer’s disease (AD), through the oral–brain axis. This review synthesizes current evidence on the pathways linking oral microbiota to cognitive decline, integrating microbial, immunological, and vascular perspectives. Oral pathogens may access the central nervous system via hematogenous dissemination or neural routes, including the trigeminal nerve, while simultaneously promoting systemic inflammation, immune activation, and blood–brain barrier disruption. These processes converge on key neurodegenerative mechanisms, including chronic neuroinflammation, amyloid-β accumulation, and tau pathology. In parallel, alterations in oral microbial composition have been linked to disease severity, supporting a potential role of dysbiosis in both initiation and progression of cognitive impairment. Diet emerges as a critical modifiable determinant of oral microbial ecology. Diets rich in refined sugars may promote dysbiosis and inflammatory signaling, whereas (poly)phenols, probiotics, and prebiotics may support microbial eubiosis and exert neuroprotective effects through modulation of host–microbe interactions. Although current evidence remains largely observational and mechanistic, the diet–oral microbiota–brain axis represents a promising target for preventive and therapeutic strategies aimed at mitigating cognitive decline and promoting healthy aging. Future longitudinal and interventional studies are required to establish causality and translate these insights into clinical practice.
Cryptocurrency Market Trends: A Machine Learning-Driven Time Series Forecasting with Twitter Sentiment Integration
Accurate forecasting of cryptocurrency prices remains an open challenge because classical statistical models cannot capture the non-linear, sentiment-driven dynamics of these markets. This study compares three hybrid deep learning architectures—VAR-LSTM, XGBoost-LSTM, and CNN-LSTM—to determine which best forecasts Bitcoin (BTC), Ethereum (ETH), and Dogecoin (DOGE) closing prices, and to quantify the marginal predictive value of Twitter sentiment integration. Six years of hourly OHLCV data (2017–2023) are augmented with VADER-scored Twitter sentiment polarity. Each model is formulated mathematically, implemented with documented hyperparameters (epochs, dropout, units;), and trained for one-step-ahead next-hour price prediction. Performance is measured by RMSE, MAE, MAPE, R 2 , and Directional Accuracy (DA) across five random seeds, with paired Wilcoxon significance tests. XGBoost-LSTM achieves the best performance (RMSE = 81.547, R 2 = 0.9254, DA = 80.0%), outperforming all nine literature baselines. Removing Twitter sentiment degrades DA by 14.3 percentage points ( p < 0.01 ), confirming that social media signals carry independent predictive information. Hybrid architectures consistently outperform single-model baselines; XGBoost-LSTM offers the best accuracy-to-compute ratio. VADER-enriched Twitter sentiment is a significant predictor beyond price history. Limitations include reliance on a single sentiment platform and a training window that predates several structural market events
Consumption of ultra-processed foods is associated with cognitive status in elderly patients
Background: Emerging evidence suggests that there might be an association between excess consumption of ultra-processed foods (UPFs) on cognitive health. UPF intake could promote systemic inflammation, oxidative stress phenomena, and metabolic dysregulation, contributing to neurodegeneration onset and cognitive decline in elderly population.Aim: The aim of this cross-sectional study was to examine the relation between UPF dietary pattern on MCI status in elderly patients taking into account the contribution of inflammatory markers.Design: The dietary intake was assessed using a validated food frequency questionnaire in ninety-two participants. All reported food items were categorized according to the NOVA system, classifying foods on the basis of the extent and purpose of industrial processing. Plasmatic concentrations of TGF-β1 and TNF-ɑ were measured by ELISA assay at the time of baseline neuropsychological evaluation. The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were administered to evaluate the cognitive function in all participants. Non-parametric tests, correlation analysis, and logistic regression models were performed to assess the relations between variables of interest.Results: No significant associations were observed for unprocessed/minimally processed foods, culinary processed foods, or processed foods across the different regression models. In contrast, higher consumption of UPF was associated with increased odds of MCI (adjusted OR = 4.24, 95% CI: 1.05–17.13). However, after additional adjustment for inflammatory biomarkers (TGF-β and TNF-α), the association was attenuated and no longer statistically significant (OR = 4.79, 95% CI: 0.73–31.24), although the direction of the association remained positive.Conclusion: UPF consumption may be associated with increased likelihood of MCI, and inflammatory status may potentially play a role in this association.
Infrared thermography to assess fatigue, injury risk factors and recovery in soccer: a systematic review of original studies
Background: Recovery after a training session or match is a key factor in injury prevention and sports performance. The purpose of this systematic review was to analyze and consolidate the available scientific evidence from the main databases on the use of infrared thermography in the assessment of fatigue, injury risk factors, and recovery in soccer players.Methods: The literature search was conducted following the PRISMA guidelines and the PICOS model until June 30, 2025, in the main scientific databases (ScienceDirect, EMBASE, Web of Science (WOS), Cochrane Library, SciELO, MEDLINE/PubMed, SPORTDiscus, and Scopus). The risk of bias and methodological quality were assessed using the Cochrane Handbook guidelines and the PEDro scale.”Results: The initial literature search yielded a total of 510 records. After applying the inclusion and exclusion criteria, the final sample consisted of 20 studies, which were of high methodological quality. The results showed the effects of infrared thermography in assessing fatigue, identifying injury risk factors, and monitoring recovery processes in soccer players. The studies also systematically reported the characterization of the population, the assessment methods used, the variables analyzed, the methodological design, the main results, and the effects of the intervention.Conclusions: Infrared thermography shows promise as a valid, reliable, and non-invasive tool for assessing skin temperature, reflecting temperature changes in response to physiological processes. It allows for the analysis of structural or metabolic fatigue and thermal asymmetries. Therefore, thermography could be used to design individualized recovery protocols.