Documentos donde el Tema es "Materias > Biomedicina"
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2026
Artículo
Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Histopathological evaluation is necessary for the diagnosis and grading of prostate cancer, which is still one of the most common cancers in men globally. Traditional evaluation is time-consuming, prone to inter-observer variability, and challenging to scale. The clinical usefulness of current AI systems is limited by the need for comprehensive pixel-level annotations. The objective of this research is to develop and evaluate a large-scale benchmarking study on a weakly supervised deep learning framework that minimizes the need for annotation and ensures interpretability for automated prostate cancer diagnosis and International Society of Urological Pathology (ISUP) grading using whole slide images (WSIs). This study rigorously tested six cutting-edge multiple instance learning (MIL) architectures (CLAM-MB, CLAM-SB, ILRA-MIL, AC-MIL, AMD-MIL, WiKG-MIL), three feature encoders (ResNet50, CTransPath, UNI2), and four patch extraction techniques (varying sizes and overlap) using the PANDA dataset (10,616 WSIs), yielding 72 experimental configurations. The methodology used distributed cloud computing to process over 31 million tissue patches, implementing advanced attention mechanisms to ensure clinical interpretability through Grad-CAM visualizations. The optimum configuration (UNI2 encoder with ILRA-MIL, 256 256 patches, 50% overlap) achieved 78.75% accuracy and 90.12% quadratic weighted kappa (QWK), outperforming traditional methods and approaching expert pathologist-level diagnostic capability. Overlapping smaller patches offered the best balance of spatial resolution and contextual information, while domain-specific foundation models performed noticeably better than generic encoders. This work is the first large-scale, comprehensive comparison of weekly supervised MIL methods for prostate cancer diagnosis and grading. The proposed approach has excellent clinical diagnostic performance, scalability, practical feasibility through cloud computing, and interpretability using visualization tools. Butt, Naveed Anwer; Sarwat, Dilawaiz; Delgado Noya, Irene; Tutusaus, Kilian; Samee, Nagwan Abdel y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, irene.delgado@uneatlantico.es, kilian.tutusaus@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Histopathological evaluation is necessary for the diagnosis and grading of prostate cancer, which is still one of the most common cancers in men globally. Traditional evaluation is time-consuming, prone to inter-observer variability, and challenging to scale. The clinical usefulness of current AI systems is limited by the need for comprehensive pixel-level annotations. The objective of this research is to develop and evaluate a large-scale benchmarking study on a weakly supervised deep learning framework that minimizes the need for annotation and ensures interpretability for automated prostate cancer diagnosis and International Society of Urological Pathology (ISUP) grading using whole slide images (WSIs). This study rigorously tested six cutting-edge multiple instance learning (MIL) architectures (CLAM-MB, CLAM-SB, ILRA-MIL, AC-MIL, AMD-MIL, WiKG-MIL), three feature encoders (ResNet50, CTransPath, UNI2), and four patch extraction techniques (varying sizes and overlap) using the PANDA dataset (10,616 WSIs), yielding 72 experimental configurations. The methodology used distributed cloud computing to process over 31 million tissue patches, implementing advanced attention mechanisms to ensure clinical interpretability through Grad-CAM visualizations. The optimum configuration (UNI2 encoder with ILRA-MIL, 256 256 patches, 50% overlap) achieved 78.75% accuracy and 90.12% quadratic weighted kappa (QWK), outperforming traditional methods and approaching expert pathologist-level diagnostic capability. Overlapping smaller patches offered the best balance of spatial resolution and contextual information, while domain-specific foundation models performed noticeably better than generic encoders. This work is the first large-scale, comprehensive comparison of weekly supervised MIL methods for prostate cancer diagnosis and grading. The proposed approach has excellent clinical diagnostic performance, scalability, practical feasibility through cloud computing, and interpretability using visualization tools. Butt, Naveed Anwer; Sarwat, Dilawaiz; Delgado Noya, Irene; Tutusaus, Kilian; Samee, Nagwan Abdel y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, irene.delgado@uneatlantico.es, kilian.tutusaus@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Benchmarking multiple instance learning architectures from patches to pathology for prostate cancer detection and grading using attention-based weak supervision.
Artículo
Materias > Biomedicina
Materias > Alimentación Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Background Age-related structural changes in the human brain, including cortical atrophy, reductions in grey and white matter volumes, and the accumulation of small vessel–related lesions such as white matter hyperintensities (WMH) and cerebral microbleeds, represent critical biological substrates underlying cognitive decline and dementia. Fish consumption has been associated with slower cognitive decline and reduced risk of dementia, but a comprehensive evaluation of its relation with brain structures is lacking. Aims The aim of this study was to systematically review current scientific literature providing evidence of relation between fish intake and brain structures in human studies. Methods Studies indexed in two major electronic databases have been screened based on a combination of keywords and MeSH terms. Studies were eligible whether they assessed fish consumption in relation to brain structures in the adult populations. Results A total of 24 studies conducted predominantly on older adults met inclusion criteria. Most brain volume measures were obtained via magnetic resonance imaging (MRI) procedures. Higher fish consumption was associated with reduced severity of white matter hyperintensities (a biomarker of cerebral small vessel disease and white matter damage) and cerebral micro-bleed, preservation of certain brain areas volumes (i.e., hippocampus, temporal lobe and periventricle white matter) and cortical thickness of specific areas (i.e., precuneus, parietal, and cingulate grey matter), among others, compared to lower intake. Some analyses found no association and isolated findings suggested possible adverse associations that were not consistently replicated. Studies reporting null findings may underline the possible relevance of the overall diet (i.e., adherence to the Mediterranean diet). Conclusions Inclusion of fish in a healthy and balanced diet is associated with better white matter grades on MRI and slower progression of white matter hyperintensities and reduction of vascular-related lesions of the aging brain, suggesting a potential role in preventing neurocognitive deterioration. Heterogeneity across studies underscores the need for additional studies. Godos, Justyna; Caruso, Giuseppe; Micek, Agnieszka; Dolci, Alberto; Ungvari, Zoltan; Lehoczki, Andrea; León Brizuela, Lisandra; Frias-Toral, Evelyn; Di Mauro, Andrea; Siervo, Mario; Di Rosa, Michelino y Grosso, Giuseppe SIN ESPECIFICAR
Materias > Alimentación Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Background Age-related structural changes in the human brain, including cortical atrophy, reductions in grey and white matter volumes, and the accumulation of small vessel–related lesions such as white matter hyperintensities (WMH) and cerebral microbleeds, represent critical biological substrates underlying cognitive decline and dementia. Fish consumption has been associated with slower cognitive decline and reduced risk of dementia, but a comprehensive evaluation of its relation with brain structures is lacking. Aims The aim of this study was to systematically review current scientific literature providing evidence of relation between fish intake and brain structures in human studies. Methods Studies indexed in two major electronic databases have been screened based on a combination of keywords and MeSH terms. Studies were eligible whether they assessed fish consumption in relation to brain structures in the adult populations. Results A total of 24 studies conducted predominantly on older adults met inclusion criteria. Most brain volume measures were obtained via magnetic resonance imaging (MRI) procedures. Higher fish consumption was associated with reduced severity of white matter hyperintensities (a biomarker of cerebral small vessel disease and white matter damage) and cerebral micro-bleed, preservation of certain brain areas volumes (i.e., hippocampus, temporal lobe and periventricle white matter) and cortical thickness of specific areas (i.e., precuneus, parietal, and cingulate grey matter), among others, compared to lower intake. Some analyses found no association and isolated findings suggested possible adverse associations that were not consistently replicated. Studies reporting null findings may underline the possible relevance of the overall diet (i.e., adherence to the Mediterranean diet). Conclusions Inclusion of fish in a healthy and balanced diet is associated with better white matter grades on MRI and slower progression of white matter hyperintensities and reduction of vascular-related lesions of the aging brain, suggesting a potential role in preventing neurocognitive deterioration. Heterogeneity across studies underscores the need for additional studies. Godos, Justyna; Caruso, Giuseppe; Micek, Agnieszka; Dolci, Alberto; Ungvari, Zoltan; Lehoczki, Andrea; León Brizuela, Lisandra; Frias-Toral, Evelyn; Di Mauro, Andrea; Siervo, Mario; Di Rosa, Michelino y Grosso, Giuseppe SIN ESPECIFICAR
Fish consumption and brain structure: a comprehensive systematic review of observational studies.
Artículo
Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés This study presents a novel integrative approach for the analysis of high-dimensional gene expression data, leveraging the complementary strengths of unsupervised clustering and supervised classification. Using K-means clustering, the dataset is stratified into three distinct clusters, revealing intrinsic biological patterns and relationships. The resulting cluster assignments are subsequently employed as pseudo-labels to train machine learning models, including support vector machines, random forest, and a stacking ensemble classifier. To validate and enhance the robustness of clustering, complementary methodologies such as hierarchical clustering and DBSCAN are employed, with results visualized through PCA-driven dimensionality reduction. The high predictive accuracy achieved by the classifiers underscores the separability and reliability of the identified clusters. Furthermore, feature importance analysis highlighted key genetic determinants within each cluster, offering actionable insights into potential biomarkers and critical genomic features. This framework bridges the gap between exploratory unsupervised learning and predictive supervised modeling, providing a scalable and interpretable methodology for analyzing complex genomic datasets. Its applicability extends to biomarker discovery, patient stratification, and other precision medicine applications, emphasizing its utility in advancing genomic research and clinical practice. Iman, Eshmal; Jabbar, Sohail; Ramzan, Shabana; Raza, Ali; Raoof, Farwa; Carvajal-Altamiranda, Stefanía; Lipari, Vivian y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, stefania.carvajal@uneatlantico.es, vivian.lipari@uneatlantico.es, SIN ESPECIFICAR
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés This study presents a novel integrative approach for the analysis of high-dimensional gene expression data, leveraging the complementary strengths of unsupervised clustering and supervised classification. Using K-means clustering, the dataset is stratified into three distinct clusters, revealing intrinsic biological patterns and relationships. The resulting cluster assignments are subsequently employed as pseudo-labels to train machine learning models, including support vector machines, random forest, and a stacking ensemble classifier. To validate and enhance the robustness of clustering, complementary methodologies such as hierarchical clustering and DBSCAN are employed, with results visualized through PCA-driven dimensionality reduction. The high predictive accuracy achieved by the classifiers underscores the separability and reliability of the identified clusters. Furthermore, feature importance analysis highlighted key genetic determinants within each cluster, offering actionable insights into potential biomarkers and critical genomic features. This framework bridges the gap between exploratory unsupervised learning and predictive supervised modeling, providing a scalable and interpretable methodology for analyzing complex genomic datasets. Its applicability extends to biomarker discovery, patient stratification, and other precision medicine applications, emphasizing its utility in advancing genomic research and clinical practice. Iman, Eshmal; Jabbar, Sohail; Ramzan, Shabana; Raza, Ali; Raoof, Farwa; Carvajal-Altamiranda, Stefanía; Lipari, Vivian y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, stefania.carvajal@uneatlantico.es, vivian.lipari@uneatlantico.es, SIN ESPECIFICAR
An Integrated Machine Learning and Genomic Framework for Precise Detection of Gastric Cancer.
2025
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Background Nowadays, there is no correlation between levels of cortisol and pain in the prehospital setting. The aim of this work was to determine the ability of prehospital cortisol levels to correlate to pain. Cortisol levels were compared with those of the numerical rating scale (NRS). Methods This is a prospective observational study looking at adult patients with acute disease managed by Emergency Medical Services (EMS) and transferred to the emergency department of two tertiary care hospitals. Epidemiological variables, vital signs, and prehospital blood analysis data were collected. A total of 1516 patients were included, the median age was 67 years (IQR: 51–79; range: 18–103) with 42.7% of females. The primary outcome was pain evaluation by NRS, which was categorized as pain-free (0 points), mild (1–3), moderate (4–6), or severe (≥7). Analysis of variance, correlation, and classification capacity in the form area under the curve of the receiver operating characteristic (AUC) curve were used to prospectively evaluate the association of cortisol with NRS. Results The median NRS and cortisol level are 1 point (IQR: 0–4) and 282 nmol/L (IQR: 143–433). There are 584 pain-free patients (38.5%), 525 mild (34.6%), 244 moderate (16.1%), and 163 severe pain (10.8%). Cortisol levels in each NRS category result in p < 0.001. The correlation coefficient between the cortisol level and NRS is 0.87 (p < 0.001). The AUC of cortisol to classify patients into each NRS category is 0.882 (95% CI: 0.853–0.910), 0.496 (95% CI: 0.446–0.545), 0.837 (95% CI: 0.803–0.872), and 0.981 (95% CI: 0.970–0.991) for the pain-free, mild, moderate, and severe categories, respectively. Conclusions Cortisol levels show similar pain evaluation as NRS, with high-correlation for NRS pain categories, except for mild-pain. Therefore, cortisol evaluation via the EMS could provide information regarding pain status. López-Izquierdo, Raúl; Ingelmo-Astorga, Elisa A.; del Pozo Vegas, Carlos; Gracia Villar, Santos; Dzul López, Luis Alonso; Aparicio Obregón, Silvia; Calderón Iglesias, Rubén; Sanz-García, Ancor y Martín-Rodríguez, Francisco SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, santos.gracia@uneatlantico.es, luis.dzul@uneatlantico.es, silvia.aparicio@uneatlantico.es, ruben.calderon@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Background Nowadays, there is no correlation between levels of cortisol and pain in the prehospital setting. The aim of this work was to determine the ability of prehospital cortisol levels to correlate to pain. Cortisol levels were compared with those of the numerical rating scale (NRS). Methods This is a prospective observational study looking at adult patients with acute disease managed by Emergency Medical Services (EMS) and transferred to the emergency department of two tertiary care hospitals. Epidemiological variables, vital signs, and prehospital blood analysis data were collected. A total of 1516 patients were included, the median age was 67 years (IQR: 51–79; range: 18–103) with 42.7% of females. The primary outcome was pain evaluation by NRS, which was categorized as pain-free (0 points), mild (1–3), moderate (4–6), or severe (≥7). Analysis of variance, correlation, and classification capacity in the form area under the curve of the receiver operating characteristic (AUC) curve were used to prospectively evaluate the association of cortisol with NRS. Results The median NRS and cortisol level are 1 point (IQR: 0–4) and 282 nmol/L (IQR: 143–433). There are 584 pain-free patients (38.5%), 525 mild (34.6%), 244 moderate (16.1%), and 163 severe pain (10.8%). Cortisol levels in each NRS category result in p < 0.001. The correlation coefficient between the cortisol level and NRS is 0.87 (p < 0.001). The AUC of cortisol to classify patients into each NRS category is 0.882 (95% CI: 0.853–0.910), 0.496 (95% CI: 0.446–0.545), 0.837 (95% CI: 0.803–0.872), and 0.981 (95% CI: 0.970–0.991) for the pain-free, mild, moderate, and severe categories, respectively. Conclusions Cortisol levels show similar pain evaluation as NRS, with high-correlation for NRS pain categories, except for mild-pain. Therefore, cortisol evaluation via the EMS could provide information regarding pain status. López-Izquierdo, Raúl; Ingelmo-Astorga, Elisa A.; del Pozo Vegas, Carlos; Gracia Villar, Santos; Dzul López, Luis Alonso; Aparicio Obregón, Silvia; Calderón Iglesias, Rubén; Sanz-García, Ancor y Martín-Rodríguez, Francisco SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, santos.gracia@uneatlantico.es, luis.dzul@uneatlantico.es, silvia.aparicio@uneatlantico.es, ruben.calderon@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Association between blood cortisol levels and numerical rating scale in prehospital pain assessment.
Artículo
Materias > Biomedicina
Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Fasting–feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal timing underscores the importance of maintaining circadian alignment in order to avoid creating a metabolic environment conducive to carcinogenesis following the molecular and systemic disruption of metabolic performance and immune function. The chronicity of such a condition may support the initiation and progression of cancer through a variety of mechanisms, including increased oxidative stress, immune suppression, and the activation of proliferative signaling pathways. This review aims to summarize current evidence from human studies and provide an overview of the potential mechanisms underscoring the role of chrononutrition (including time-restricted eating) on cancer risk. Current evidence shows that the morning chronotype, suggesting an alignment between physiological circadian rhythms and eating timing, is associated with a lower risk of cancer. Also, early time-restricted eating and prolonged nighttime fasting were also associated with a lower risk of cancer. The current evidence suggests that the chronotype influences cancer risk through cell cycle regulation, the modulation of metabolic pathways and inflammation, and gut microbiota fluctuations. In conclusion, although there are no clear guidelines on this matter, emerging evidence supports the hypothesis that the role of time-related eating (i.e., time/calorie-restricted feeding and intermittent/periodic fasting) could potentially lead to a reduced risk of cancer. Godos, Justyna; Currenti, Walter; Ferri, Raffaele; Lanza, Giuseppe; Caraci, Filippo; Frias-Toral, Evelyn; Guglielmetti, Monica; Ferraris, Cinzia; Lipari, Vivian; Carvajal Altamiranda, Stefanía; Galvano, Fabio; Castellano, Sabrina y Grosso, Giuseppe SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, stefania.carvajal@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR
Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Fasting–feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal timing underscores the importance of maintaining circadian alignment in order to avoid creating a metabolic environment conducive to carcinogenesis following the molecular and systemic disruption of metabolic performance and immune function. The chronicity of such a condition may support the initiation and progression of cancer through a variety of mechanisms, including increased oxidative stress, immune suppression, and the activation of proliferative signaling pathways. This review aims to summarize current evidence from human studies and provide an overview of the potential mechanisms underscoring the role of chrononutrition (including time-restricted eating) on cancer risk. Current evidence shows that the morning chronotype, suggesting an alignment between physiological circadian rhythms and eating timing, is associated with a lower risk of cancer. Also, early time-restricted eating and prolonged nighttime fasting were also associated with a lower risk of cancer. The current evidence suggests that the chronotype influences cancer risk through cell cycle regulation, the modulation of metabolic pathways and inflammation, and gut microbiota fluctuations. In conclusion, although there are no clear guidelines on this matter, emerging evidence supports the hypothesis that the role of time-related eating (i.e., time/calorie-restricted feeding and intermittent/periodic fasting) could potentially lead to a reduced risk of cancer. Godos, Justyna; Currenti, Walter; Ferri, Raffaele; Lanza, Giuseppe; Caraci, Filippo; Frias-Toral, Evelyn; Guglielmetti, Monica; Ferraris, Cinzia; Lipari, Vivian; Carvajal Altamiranda, Stefanía; Galvano, Fabio; Castellano, Sabrina y Grosso, Giuseppe SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, stefania.carvajal@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR
Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies.
Artículo
Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Background Deep learning models assist ophthalmologists in early detection of diseases from retinal images and timely treatment. Aim Owing to robust and accurate results from deep learning models, we aim to use convolutional neural network (CNN) to provide a non-invasive method for early detection of eye diseases. Methodology We used a hybridized CNN with deep learning (DL) based on two separate CNN blocks, to identify multiple Optic Disc Cupping, Diabetic Retinopathy, Media Haze, and Healthy images. We used the RFMiD dataset, which contains various categories of fundus images representing different eye diseases. Data augmenting, resizing, coping, and one-hot encoding are used among other preprocessing techniques to improve the performance of the proposed model. Color fundus images have been analyzed by CNNs to extract relevant features. Two CCN models that extract deep features are trained in parallel. To obtain more noticeable features, the gathered features are further fused utilizing the Canonical Correlation Analysis fusion approach. To assess the effectiveness, we employed eight classification algorithms: Gradient boosting, support vector machines, voting ensemble, medium KNN, Naive Bayes, COARSE- KNN, random forest, and fine KNN. Results With the greatest accuracy of 93.39%, the ensemble learning performed better than the other algorithms. Conclusion The accuracy rates suggest that the deep learning model has learned to distinguish between different eye disease categories and healthy images effectively. It contributes to the field of eye disease detection through the analysis of color fundus images by providing a reliable and efficient diagnostic system. Ejaz, Sara; Zia, Hafiz U; Majeed, Fiaz; Shafique, Umair; Carvajal-Altamiranda, Stefanía; Lipari, Vivian y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, stefania.carvajal@uneatlantico.es, vivian.lipari@uneatlantico.es, SIN ESPECIFICAR
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Background Deep learning models assist ophthalmologists in early detection of diseases from retinal images and timely treatment. Aim Owing to robust and accurate results from deep learning models, we aim to use convolutional neural network (CNN) to provide a non-invasive method for early detection of eye diseases. Methodology We used a hybridized CNN with deep learning (DL) based on two separate CNN blocks, to identify multiple Optic Disc Cupping, Diabetic Retinopathy, Media Haze, and Healthy images. We used the RFMiD dataset, which contains various categories of fundus images representing different eye diseases. Data augmenting, resizing, coping, and one-hot encoding are used among other preprocessing techniques to improve the performance of the proposed model. Color fundus images have been analyzed by CNNs to extract relevant features. Two CCN models that extract deep features are trained in parallel. To obtain more noticeable features, the gathered features are further fused utilizing the Canonical Correlation Analysis fusion approach. To assess the effectiveness, we employed eight classification algorithms: Gradient boosting, support vector machines, voting ensemble, medium KNN, Naive Bayes, COARSE- KNN, random forest, and fine KNN. Results With the greatest accuracy of 93.39%, the ensemble learning performed better than the other algorithms. Conclusion The accuracy rates suggest that the deep learning model has learned to distinguish between different eye disease categories and healthy images effectively. It contributes to the field of eye disease detection through the analysis of color fundus images by providing a reliable and efficient diagnostic system. Ejaz, Sara; Zia, Hafiz U; Majeed, Fiaz; Shafique, Umair; Carvajal-Altamiranda, Stefanía; Lipari, Vivian y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, stefania.carvajal@uneatlantico.es, vivian.lipari@uneatlantico.es, SIN ESPECIFICAR
Fundus image classification using feature concatenation for early diagnosis of retinal disease.
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés The aim of the present work was to determine the correlation between the State-Trait Anxiety Inventory (STAI) score and pupillary diameter and whether this correlation exists to develop a predictive model of anxiety with the pupillary diameter of students exposed to high-fidelity clinical simulation. This was a randomized, blinded, simulation-based clinical trial. The study was conducted at the Advanced Clinical Simulation Center, Faculty of Medicine, Valladolid University (Spain), from February 1 to April 15, 2023, and involved volunteer sixth-year undergraduate medical students. The STAI score, vital signs (oxygen saturation, perfusion index, blood pressure, heart rate, and temperature), and pupillary response were assessed. The primary outcomes were the delta (pre/postsimulation) of the state STAI and the delta of the pupillary diameter. Sixty-one sixth-year students fulfilled the inclusion criteria. There was no difference regarding the clinical scenario. There was a statistically significant correlation between the state STAI score and pupillary diameter. The predictive model had an AUC of 0.876, with the delta diameter of the pupillary being the only statistically significant variable for anxiety prediction. Our results showed that both the pupillary response and the STAI score allowed the identification of students with disabling anxiety. These results could pave the way for appropriate protocol development that allows for personalized tutoring of students with elevated anxiety levels. Martín-Rodríguez, Francisco; Martín-Sánchez, Rafael; del Pozo Vegas, Carlos; Lopez-Izquierdo, Raúl; Martín-Conty, José Luis; Silva Alvarado, Eduardo René; Gracia Villar, Santos; Dzul López, Luis Alonso; Aparicio Obregón, Silvia; Calderón Iglesias, Rubén; Sanz-García, Ancor y Castro Villamor, Miguel Ángel SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, eduardo.silva@funiber.org, santos.gracia@uneatlantico.es, luis.dzul@uneatlantico.es, silvia.aparicio@uneatlantico.es, ruben.calderon@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés The aim of the present work was to determine the correlation between the State-Trait Anxiety Inventory (STAI) score and pupillary diameter and whether this correlation exists to develop a predictive model of anxiety with the pupillary diameter of students exposed to high-fidelity clinical simulation. This was a randomized, blinded, simulation-based clinical trial. The study was conducted at the Advanced Clinical Simulation Center, Faculty of Medicine, Valladolid University (Spain), from February 1 to April 15, 2023, and involved volunteer sixth-year undergraduate medical students. The STAI score, vital signs (oxygen saturation, perfusion index, blood pressure, heart rate, and temperature), and pupillary response were assessed. The primary outcomes were the delta (pre/postsimulation) of the state STAI and the delta of the pupillary diameter. Sixty-one sixth-year students fulfilled the inclusion criteria. There was no difference regarding the clinical scenario. There was a statistically significant correlation between the state STAI score and pupillary diameter. The predictive model had an AUC of 0.876, with the delta diameter of the pupillary being the only statistically significant variable for anxiety prediction. Our results showed that both the pupillary response and the STAI score allowed the identification of students with disabling anxiety. These results could pave the way for appropriate protocol development that allows for personalized tutoring of students with elevated anxiety levels. Martín-Rodríguez, Francisco; Martín-Sánchez, Rafael; del Pozo Vegas, Carlos; Lopez-Izquierdo, Raúl; Martín-Conty, José Luis; Silva Alvarado, Eduardo René; Gracia Villar, Santos; Dzul López, Luis Alonso; Aparicio Obregón, Silvia; Calderón Iglesias, Rubén; Sanz-García, Ancor y Castro Villamor, Miguel Ángel SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, eduardo.silva@funiber.org, santos.gracia@uneatlantico.es, luis.dzul@uneatlantico.es, silvia.aparicio@uneatlantico.es, ruben.calderon@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Pupilometer efficacy in monitoring anxiety in undergraduate medical students during high-fidelity clinical simulation.
2024
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Emergency medical services (EMSs) face critical situations that require patient risk classification based on analytical and vital signs. We aimed to establish clustering-derived phenotypes based on prehospital analytical and vital signs that allow risk stratification. This was a prospective, multicenter, EMS-delivered, ambulance-based cohort study considering six advanced life support units, 38 basic life support units, and four tertiary hospitals in Spain. Adults with unselected acute diseases managed by the EMS and evacuated with discharge priority to emergency departments were considered between January 1, 2020, and June 30, 2023. Prehospital point-of-care testing and on-scene vital signs were used for the unsupervised machine learning method (clustering) to determine the phenotypes. Then phenotypes were compared with the primary outcome (cumulative mortality (all-cause) at 2, 7, and 30 days). A total of 7909 patients were included. The median (IQR) age was 64 (51–80) years, 41% were women, and 26% were living in rural areas. Three clusters were identified: alpha 16.2% (1281 patients), beta 28.8% (2279), and gamma 55% (4349). The mortality rates for alpha, beta and gamma at 2 days were 18.6%, 4.1%, and 0.8%, respectively; at 7 days, were 24.7%, 6.2%, and 1.7%; and at 30 days, were 33%, 10.2%, and 3.2%, respectively. Based on standard vital signs and blood test biomarkers in the prehospital scenario, three clusters were identified: alpha (high-risk), beta and gamma (medium- and low-risk, respectively). This permits the EMS system to quickly identify patients who are potentially compromised and to proactively implement the necessary interventions. López-Izquierdo, Raúl; del Pozo Vegas, Carlos; Sanz-García, Ancor; Mayo Íscar, Agustín; Castro Villamor, Miguel A.; Silva Alvarado, Eduardo René; Gracia Villar, Santos; Dzul López, Luis Alonso; Aparicio Obregón, Silvia; Calderón Iglesias, Rubén; Soriano, Joan B. y Martín-Rodríguez, Francisco SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, eduardo.silva@funiber.org, santos.gracia@uneatlantico.es, luis.dzul@uneatlantico.es, silvia.aparicio@uneatlantico.es, ruben.calderon@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Emergency medical services (EMSs) face critical situations that require patient risk classification based on analytical and vital signs. We aimed to establish clustering-derived phenotypes based on prehospital analytical and vital signs that allow risk stratification. This was a prospective, multicenter, EMS-delivered, ambulance-based cohort study considering six advanced life support units, 38 basic life support units, and four tertiary hospitals in Spain. Adults with unselected acute diseases managed by the EMS and evacuated with discharge priority to emergency departments were considered between January 1, 2020, and June 30, 2023. Prehospital point-of-care testing and on-scene vital signs were used for the unsupervised machine learning method (clustering) to determine the phenotypes. Then phenotypes were compared with the primary outcome (cumulative mortality (all-cause) at 2, 7, and 30 days). A total of 7909 patients were included. The median (IQR) age was 64 (51–80) years, 41% were women, and 26% were living in rural areas. Three clusters were identified: alpha 16.2% (1281 patients), beta 28.8% (2279), and gamma 55% (4349). The mortality rates for alpha, beta and gamma at 2 days were 18.6%, 4.1%, and 0.8%, respectively; at 7 days, were 24.7%, 6.2%, and 1.7%; and at 30 days, were 33%, 10.2%, and 3.2%, respectively. Based on standard vital signs and blood test biomarkers in the prehospital scenario, three clusters were identified: alpha (high-risk), beta and gamma (medium- and low-risk, respectively). This permits the EMS system to quickly identify patients who are potentially compromised and to proactively implement the necessary interventions. López-Izquierdo, Raúl; del Pozo Vegas, Carlos; Sanz-García, Ancor; Mayo Íscar, Agustín; Castro Villamor, Miguel A.; Silva Alvarado, Eduardo René; Gracia Villar, Santos; Dzul López, Luis Alonso; Aparicio Obregón, Silvia; Calderón Iglesias, Rubén; Soriano, Joan B. y Martín-Rodríguez, Francisco SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, eduardo.silva@funiber.org, santos.gracia@uneatlantico.es, luis.dzul@uneatlantico.es, silvia.aparicio@uneatlantico.es, ruben.calderon@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Clinical phenotypes and short-term outcomes based on prehospital point-of-care testing and on-scene vital signs.
Artículo
Materias > Biomedicina
Materias > Ciencias Sociales
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Aim: The development of predictive models for patients treated by emergency medical services (EMS) is on the rise in the emergency field. However, how these models evolve over time has not been studied. The objective of the present work is to compare the characteristics of patients who present mortality in the short, medium and long term, and to derive and validate a predictive model for each mortality time. Methods: A prospective multicenter study was conducted, which included adult patients with unselected acute illness who were treated by EMS. The primary outcome was noncumulative mortality from all causes by time windows including 30-day mortality, 31- to 180-day mortality, and 181- to 365-day mortality. Prehospital predictors included demographic variables, standard vital signs, prehospital laboratory tests, and comorbidities. Results: A total of 4830 patients were enrolled. The noncumulative mortalities at 30, 180, and 365 days were 10.8%, 6.6%, and 3.5%, respectively. The best predictive value was shown for 30-day mortality (AUC = 0.930; 95% CI: 0.919–0.940), followed by 180-day (AUC = 0.852; 95% CI: 0.832–0.871) and 365-day (AUC = 0.806; 95% CI: 0.778–0.833) mortality. Discussion: Rapid characterization of patients at risk of short-, medium-, or long-term mortality could help EMS to improve the treatment of patients suffering from acute illnesses. Enriquez de Salamanca Gambara, Rodrigo; Sanz-García, Ancor; del Pozo Vegas, Carlos; López-Izquierdo, Raúl; Sánchez Soberón, Irene; Delgado Benito, Juan F.; Martínez Díaz, Raquel; Mazas Pérez-Oleaga, Cristina; Martínez López, Nohora Milena; Dominguez Azpíroz, Irma y Martín-Rodríguez, Francisco SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, raquel.martinez@uneatlantico.es, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, irma.dominguez@unini.edu.mx, SIN ESPECIFICAR
Materias > Ciencias Sociales
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Aim: The development of predictive models for patients treated by emergency medical services (EMS) is on the rise in the emergency field. However, how these models evolve over time has not been studied. The objective of the present work is to compare the characteristics of patients who present mortality in the short, medium and long term, and to derive and validate a predictive model for each mortality time. Methods: A prospective multicenter study was conducted, which included adult patients with unselected acute illness who were treated by EMS. The primary outcome was noncumulative mortality from all causes by time windows including 30-day mortality, 31- to 180-day mortality, and 181- to 365-day mortality. Prehospital predictors included demographic variables, standard vital signs, prehospital laboratory tests, and comorbidities. Results: A total of 4830 patients were enrolled. The noncumulative mortalities at 30, 180, and 365 days were 10.8%, 6.6%, and 3.5%, respectively. The best predictive value was shown for 30-day mortality (AUC = 0.930; 95% CI: 0.919–0.940), followed by 180-day (AUC = 0.852; 95% CI: 0.832–0.871) and 365-day (AUC = 0.806; 95% CI: 0.778–0.833) mortality. Discussion: Rapid characterization of patients at risk of short-, medium-, or long-term mortality could help EMS to improve the treatment of patients suffering from acute illnesses. Enriquez de Salamanca Gambara, Rodrigo; Sanz-García, Ancor; del Pozo Vegas, Carlos; López-Izquierdo, Raúl; Sánchez Soberón, Irene; Delgado Benito, Juan F.; Martínez Díaz, Raquel; Mazas Pérez-Oleaga, Cristina; Martínez López, Nohora Milena; Dominguez Azpíroz, Irma y Martín-Rodríguez, Francisco SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, raquel.martinez@uneatlantico.es, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, irma.dominguez@unini.edu.mx, SIN ESPECIFICAR
A Comparison of the Clinical Characteristics of Short-, Mid-, and Long-Term Mortality in Patients Attended by the Emergency Medical Services: An Observational Study.
Artículo
Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Non-Insulin-Dependent Diabetes Mellitus (NIDDM) is a chronic health condition caused by high blood sugar levels, and if not treated early, it can lead to serious complications i.e. blindness. Human Activity Recognition (HAR) offers potential for early NIDDM diagnosis, emerging as a key application for HAR technology. This research introduces DiabSense, a state-of-the-art smartphone-dependent system for early staging of NIDDM. DiabSense incorporates HAR and Diabetic Retinopathy (DR) upon leveraging the power of two different Graph Neural Networks (GNN). HAR uses a comprehensive array of 23 human activities resembling Diabetes symptoms, and DR is a prevalent complication of NIDDM. Graph Attention Network (GAT) in HAR achieved 98.32% accuracy on sensor data, while Graph Convolutional Network (GCN) in the Aptos 2019 dataset scored 84.48%, surpassing other state-of-the-art models. The trained GCN analyzed retinal images of four experimental human subjects for DR report generation, and GAT generated their average duration of daily activities over 30 days. The daily activities in non-diabetic periods of diabetic patients were measured and compared with the daily activities of the experimental subjects, which helped generate risk factors. Fusing risk factors with DR conditions enabled early diagnosis recommendations for the experimental subjects despite the absence of any apparent symptoms. The comparison of DiabSense system outcome with clinical diagnosis reports in the experimental subjects was conducted using the A1C test. The test results confirmed the accurate assessment of early diagnosis requirements for experimental subjects by the system. Overall, DiabSense exhibits significant potential for ensuring early NIDDM treatment, improving millions of lives worldwide. Alam, Md Nuho Ul; Hasnine, Ibrahim; Bahadur, Erfanul Hoque; Masum, Abdul Kadar Muhammad; Briones Urbano, Mercedes; Masías Vergara, Manuel; Uddin, Jia; Ashraf, Imran y Samad, Md. Abdus SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, mercedes.briones@uneatlantico.es, manuel.masias@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Non-Insulin-Dependent Diabetes Mellitus (NIDDM) is a chronic health condition caused by high blood sugar levels, and if not treated early, it can lead to serious complications i.e. blindness. Human Activity Recognition (HAR) offers potential for early NIDDM diagnosis, emerging as a key application for HAR technology. This research introduces DiabSense, a state-of-the-art smartphone-dependent system for early staging of NIDDM. DiabSense incorporates HAR and Diabetic Retinopathy (DR) upon leveraging the power of two different Graph Neural Networks (GNN). HAR uses a comprehensive array of 23 human activities resembling Diabetes symptoms, and DR is a prevalent complication of NIDDM. Graph Attention Network (GAT) in HAR achieved 98.32% accuracy on sensor data, while Graph Convolutional Network (GCN) in the Aptos 2019 dataset scored 84.48%, surpassing other state-of-the-art models. The trained GCN analyzed retinal images of four experimental human subjects for DR report generation, and GAT generated their average duration of daily activities over 30 days. The daily activities in non-diabetic periods of diabetic patients were measured and compared with the daily activities of the experimental subjects, which helped generate risk factors. Fusing risk factors with DR conditions enabled early diagnosis recommendations for the experimental subjects despite the absence of any apparent symptoms. The comparison of DiabSense system outcome with clinical diagnosis reports in the experimental subjects was conducted using the A1C test. The test results confirmed the accurate assessment of early diagnosis requirements for experimental subjects by the system. Overall, DiabSense exhibits significant potential for ensuring early NIDDM treatment, improving millions of lives worldwide. Alam, Md Nuho Ul; Hasnine, Ibrahim; Bahadur, Erfanul Hoque; Masum, Abdul Kadar Muhammad; Briones Urbano, Mercedes; Masías Vergara, Manuel; Uddin, Jia; Ashraf, Imran y Samad, Md. Abdus SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, mercedes.briones@uneatlantico.es, manuel.masias@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR
DiabSense: early diagnosis of non-insulin-dependent diabetes mellitus using smartphone-based human activity recognition and diabetic retinopathy analysis with Graph Neural Network.
Artículo
Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Thyroid illness encompasses a range of disorders affecting the thyroid gland, leading to either hyperthyroidism or hypothyroidism, which can significantly impact metabolism and overall health. Hypothyroidism can cause a slowdown in bodily processes, leading to symptoms such as fatigue, weight gain, depression, and cold sensitivity. Hyperthyroidism can lead to increased metabolism, causing symptoms like rapid weight loss, anxiety, irritability, and heart palpitations. Prompt diagnosis and appropriate treatment are crucial in managing thyroid disorders and improving patients’ quality of life. Thyroid illness affects millions worldwide and can significantly impact their quality of life if left untreated. This research aims to propose an effective artificial intelligence-based approach for the early diagnosis of thyroid illness. An open-access thyroid disease dataset based on 3,772 male and female patient observations is used for this research experiment. This study uses the nominal continuous synthetic minority oversampling technique (SMOTE-NC) for data balancing and a fine-tuned light gradient booster machine (LGBM) technique to diagnose thyroid illness and handle class imbalance problems. The proposed SNL (SMOTE-NC-LGBM) approach outperformed the state-of-the-art approach with high-accuracy performance scores of 0.96. We have also applied advanced machine learning and deep learning methods for comparison to evaluate performance. Hyperparameter optimizations are also conducted to enhance thyroid diagnosis performance. In addition, we have applied the explainable Artificial Intelligence (XAI) mechanism based on Shapley Additive exPlanations (SHAP) to enhance the transparency and interpretability of the proposed method by analyzing the decision-making processes. The proposed research revolutionizes the diagnosis of thyroid disorders efficiently and helps specialties overcome thyroid disorders early. Raza, Ali; Eid, Fatma; Caro Montero, Elisabeth; Delgado Noya, Irene y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, elizabeth.caro@uneatlantico.es, irene.delgado@uneatlantico.es, SIN ESPECIFICAR
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Thyroid illness encompasses a range of disorders affecting the thyroid gland, leading to either hyperthyroidism or hypothyroidism, which can significantly impact metabolism and overall health. Hypothyroidism can cause a slowdown in bodily processes, leading to symptoms such as fatigue, weight gain, depression, and cold sensitivity. Hyperthyroidism can lead to increased metabolism, causing symptoms like rapid weight loss, anxiety, irritability, and heart palpitations. Prompt diagnosis and appropriate treatment are crucial in managing thyroid disorders and improving patients’ quality of life. Thyroid illness affects millions worldwide and can significantly impact their quality of life if left untreated. This research aims to propose an effective artificial intelligence-based approach for the early diagnosis of thyroid illness. An open-access thyroid disease dataset based on 3,772 male and female patient observations is used for this research experiment. This study uses the nominal continuous synthetic minority oversampling technique (SMOTE-NC) for data balancing and a fine-tuned light gradient booster machine (LGBM) technique to diagnose thyroid illness and handle class imbalance problems. The proposed SNL (SMOTE-NC-LGBM) approach outperformed the state-of-the-art approach with high-accuracy performance scores of 0.96. We have also applied advanced machine learning and deep learning methods for comparison to evaluate performance. Hyperparameter optimizations are also conducted to enhance thyroid diagnosis performance. In addition, we have applied the explainable Artificial Intelligence (XAI) mechanism based on Shapley Additive exPlanations (SHAP) to enhance the transparency and interpretability of the proposed method by analyzing the decision-making processes. The proposed research revolutionizes the diagnosis of thyroid disorders efficiently and helps specialties overcome thyroid disorders early. Raza, Ali; Eid, Fatma; Caro Montero, Elisabeth; Delgado Noya, Irene y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, elizabeth.caro@uneatlantico.es, irene.delgado@uneatlantico.es, SIN ESPECIFICAR
Enhanced interpretable thyroid disease diagnosis by leveraging synthetic oversampling and machine learning models.
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Background: The 2023 dengue outbreak has proven that dengue is not only an endemic disease but also an emerging health threat in Bangladesh. Integrated studies on the epidemiology, clinical characteristics, seasonality, and genotype of dengue are limited. This study was conducted to determine recent trends in the molecular epidemiology, clinical features, and seasonality of dengue outbreaks. Methods: We analyzed data from 41 original studies, extracting epidemiological information from all 41 articles, clinical symptoms from 30 articles, and genotypic diversity from 11 articles. The study adhered to the standards of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement and Cochrane Collaboration guidelines. Conclusion: This study provides integrated insights into the molecular epidemiology, clinical features, seasonality, and transmission of dengue in Bangladesh and highlights research gaps for future studies. Sharif, Nadim; Opu, Rubayet Rayhan; Saha, Tama; Masud, Abdullah Ibna; Naim, Jannatin; Alsharif, Khalaf F.; Alzahrani, Khalid J.; Silva Alvarado, Eduardo René; Delgado Noya, Irene; De la Torre Díez, Isabel y Dey, Shuvra Kanti SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, eduardo.silva@funiber.org, irene.delgado@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Background: The 2023 dengue outbreak has proven that dengue is not only an endemic disease but also an emerging health threat in Bangladesh. Integrated studies on the epidemiology, clinical characteristics, seasonality, and genotype of dengue are limited. This study was conducted to determine recent trends in the molecular epidemiology, clinical features, and seasonality of dengue outbreaks. Methods: We analyzed data from 41 original studies, extracting epidemiological information from all 41 articles, clinical symptoms from 30 articles, and genotypic diversity from 11 articles. The study adhered to the standards of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement and Cochrane Collaboration guidelines. Conclusion: This study provides integrated insights into the molecular epidemiology, clinical features, seasonality, and transmission of dengue in Bangladesh and highlights research gaps for future studies. Sharif, Nadim; Opu, Rubayet Rayhan; Saha, Tama; Masud, Abdullah Ibna; Naim, Jannatin; Alsharif, Khalaf F.; Alzahrani, Khalid J.; Silva Alvarado, Eduardo René; Delgado Noya, Irene; De la Torre Díez, Isabel y Dey, Shuvra Kanti SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, eduardo.silva@funiber.org, irene.delgado@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Evolving epidemiology, clinical features, and genotyping of dengue outbreaks in Bangladesh, 2000–2024: a systematic review.
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés The evolution of the COVID-19 pandemic has been associated with variations in clinical presentation and severity. Similarly, prediction scores may suffer changes in their diagnostic accuracy. The aim of this study was to test the 30-day mortality predictive validity of the 4C and SEIMC scores during the sixth wave of the pandemic and to compare them with those of validation studies. This was a longitudinal retrospective observational study. COVID-19 patients who were admitted to the Emergency Department of a Spanish hospital from December 15, 2021, to January 31, 2022, were selected. A side-by-side comparison with the pivotal validation studies was subsequently performed. The main measures were 30-day mortality and the 4C and SEIMC scores. A total of 27,614 patients were considered in the study, including 22,361 from the 4C, 4,627 from the SEIMC and 626 from our hospital. The 30-day mortality rate was significantly lower than that reported in the validation studies. The AUCs were 0.931 (95% CI: 0.90–0.95) for 4C and 0.903 (95% CI: 086–0.93) for SEIMC, which were significantly greater than those obtained in the first wave. Despite the changes that have occurred during the coronavirus disease 2019 (COVID-19) pandemic, with a reduction in lethality, scorecard systems are currently still useful tools for detecting patients with poor disease risk, with better prognostic capacity. de Santos Castro, Pedro Ángel; del Pozo Vegas, Carlos; Pinilla Arribas, Leyre Teresa; Zalama Sánchez, Daniel; Sanz-García, Ancor; Vásquez del Águila, Tony Giancarlo; González Izquierdo, Pablo; de Santos Sánchez, Sara; Mazas Pérez-Oleaga, Cristina; Dominguez Azpíroz, Irma; Elío Pascual, Iñaki y Martín-Rodríguez, Francisco SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, irma.dominguez@unini.edu.mx, inaki.elio@uneatlantico.es, SIN ESPECIFICAR
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés The evolution of the COVID-19 pandemic has been associated with variations in clinical presentation and severity. Similarly, prediction scores may suffer changes in their diagnostic accuracy. The aim of this study was to test the 30-day mortality predictive validity of the 4C and SEIMC scores during the sixth wave of the pandemic and to compare them with those of validation studies. This was a longitudinal retrospective observational study. COVID-19 patients who were admitted to the Emergency Department of a Spanish hospital from December 15, 2021, to January 31, 2022, were selected. A side-by-side comparison with the pivotal validation studies was subsequently performed. The main measures were 30-day mortality and the 4C and SEIMC scores. A total of 27,614 patients were considered in the study, including 22,361 from the 4C, 4,627 from the SEIMC and 626 from our hospital. The 30-day mortality rate was significantly lower than that reported in the validation studies. The AUCs were 0.931 (95% CI: 0.90–0.95) for 4C and 0.903 (95% CI: 086–0.93) for SEIMC, which were significantly greater than those obtained in the first wave. Despite the changes that have occurred during the coronavirus disease 2019 (COVID-19) pandemic, with a reduction in lethality, scorecard systems are currently still useful tools for detecting patients with poor disease risk, with better prognostic capacity. de Santos Castro, Pedro Ángel; del Pozo Vegas, Carlos; Pinilla Arribas, Leyre Teresa; Zalama Sánchez, Daniel; Sanz-García, Ancor; Vásquez del Águila, Tony Giancarlo; González Izquierdo, Pablo; de Santos Sánchez, Sara; Mazas Pérez-Oleaga, Cristina; Dominguez Azpíroz, Irma; Elío Pascual, Iñaki y Martín-Rodríguez, Francisco SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, irma.dominguez@unini.edu.mx, inaki.elio@uneatlantico.es, SIN ESPECIFICAR
Performance of the 4C and SEIMC scoring systems in predicting mortality from onset to current COVID-19 pandemic in emergency departments.
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Cardiovascular diseases are among the leading causes of mortality worldwide, with dietary factors being the main risk contributors. Diets rich in bioactive compounds, such as (poly)phenols, have been shown to potentially exert positive effects on vascular health. Among them, resveratrol has gained particular attention due to its potential antioxidant and anti-inflammatory action. Nevertheless, the results in humans are conflicting possibly due to interindividual different responses. The gut microbiota, a complex microbial community that inhabits the gastrointestinal tract, has been called out as potentially responsible for modulating the biological activities of phenolic metabolites in humans. The present review aims to summarize the main findings from clinical trials on the effects of resveratrol interventions on endothelial and vascular outcomes and review potential mechanisms interesting the role of gut microbiota on the metabolism of this molecule and its cardioprotective metabolites. The findings from randomized controlled trials show contrasting results on the effects of resveratrol supplementation and vascular biomarkers without dose-dependent effect. In particular, studies in which resveratrol was integrated using food sources, i.e., red wine, reported significant effects although the resveratrol content was, on average, much lower compared to tablet supplementation, while other studies with often extreme resveratrol supplementation resulted in null findings. The results from experimental studies suggest that resveratrol exerts cardioprotective effects through the modulation of various antioxidant, anti-inflammatory, and anti-hypertensive pathways, and microbiota composition. Recent studies on resveratrol-derived metabolites, such as piceatannol, have demonstrated its effects on biomarkers of vascular health. Moreover, resveratrol itself has been shown to improve the gut microbiota composition toward an anti-inflammatory profile. Considering the contrasting findings from clinical studies, future research exploring the bidirectional link between resveratrol metabolism and gut microbiota as well as the mediating effect of gut microbiota in resveratrol effect on cardiovascular health is warranted. Godos, Justyna; Romano, Giovanni Luca; Gozzo, Lucia; Laudani, Samuele; Paladino, Nadia; Dominguez Azpíroz, Irma; Martínez López, Nohora Milena; Giampieri, Francesca; Quiles, José L.; Battino, Maurizio; Galvano, Fabio; Drago, Filippo y Grosso, Giuseppe SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, irma.dominguez@unini.edu.mx, nohora.martinez@uneatlantico.es, francesca.giampieri@uneatlantico.es, jose.quiles@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Cardiovascular diseases are among the leading causes of mortality worldwide, with dietary factors being the main risk contributors. Diets rich in bioactive compounds, such as (poly)phenols, have been shown to potentially exert positive effects on vascular health. Among them, resveratrol has gained particular attention due to its potential antioxidant and anti-inflammatory action. Nevertheless, the results in humans are conflicting possibly due to interindividual different responses. The gut microbiota, a complex microbial community that inhabits the gastrointestinal tract, has been called out as potentially responsible for modulating the biological activities of phenolic metabolites in humans. The present review aims to summarize the main findings from clinical trials on the effects of resveratrol interventions on endothelial and vascular outcomes and review potential mechanisms interesting the role of gut microbiota on the metabolism of this molecule and its cardioprotective metabolites. The findings from randomized controlled trials show contrasting results on the effects of resveratrol supplementation and vascular biomarkers without dose-dependent effect. In particular, studies in which resveratrol was integrated using food sources, i.e., red wine, reported significant effects although the resveratrol content was, on average, much lower compared to tablet supplementation, while other studies with often extreme resveratrol supplementation resulted in null findings. The results from experimental studies suggest that resveratrol exerts cardioprotective effects through the modulation of various antioxidant, anti-inflammatory, and anti-hypertensive pathways, and microbiota composition. Recent studies on resveratrol-derived metabolites, such as piceatannol, have demonstrated its effects on biomarkers of vascular health. Moreover, resveratrol itself has been shown to improve the gut microbiota composition toward an anti-inflammatory profile. Considering the contrasting findings from clinical studies, future research exploring the bidirectional link between resveratrol metabolism and gut microbiota as well as the mediating effect of gut microbiota in resveratrol effect on cardiovascular health is warranted. Godos, Justyna; Romano, Giovanni Luca; Gozzo, Lucia; Laudani, Samuele; Paladino, Nadia; Dominguez Azpíroz, Irma; Martínez López, Nohora Milena; Giampieri, Francesca; Quiles, José L.; Battino, Maurizio; Galvano, Fabio; Drago, Filippo y Grosso, Giuseppe SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, irma.dominguez@unini.edu.mx, nohora.martinez@uneatlantico.es, francesca.giampieri@uneatlantico.es, jose.quiles@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR
Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota.
2023
Artículo
Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Artificial intelligence has made substantial progress in medicine. Automated dental imaging interpretation is one of the most prolific areas of research using AI. X-ray and infrared imaging systems have enabled dental clinicians to identify dental diseases since the 1950s. However, the manual process of dental disease assessment is tedious and error-prone when diagnosed by inexperienced dentists. Thus, researchers have employed different advanced computer vision techniques, and machine- and deep-learning models for dental disease diagnoses using X-ray and near-infrared imagery. Despite the notable development of AI in dentistry, certain factors affect the performance of the proposed approaches, including limited data availability, imbalanced classes, and lack of transparency and interpretability. Hence, it is of utmost importance for the research community to formulate suitable approaches, considering the existing challenges and leveraging findings from the existing studies. Based on an extensive literature review, this survey provides a brief overview of X-ray and near-infrared imaging systems. Additionally, a comprehensive insight into challenges faced by researchers in the dental domain has been brought forth in this survey. The article further offers an amalgamative assessment of both performances and methods evaluated on public benchmarks and concludes with ethical considerations and future research avenues. Shafi, Imran; Fatima, Anum; Afzal, Hammad; Díez, Isabel de la Torre; Lipari, Vivian; Breñosa, Jose y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, josemanuel.brenosa@uneatlantico.es, SIN ESPECIFICAR
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Artificial intelligence has made substantial progress in medicine. Automated dental imaging interpretation is one of the most prolific areas of research using AI. X-ray and infrared imaging systems have enabled dental clinicians to identify dental diseases since the 1950s. However, the manual process of dental disease assessment is tedious and error-prone when diagnosed by inexperienced dentists. Thus, researchers have employed different advanced computer vision techniques, and machine- and deep-learning models for dental disease diagnoses using X-ray and near-infrared imagery. Despite the notable development of AI in dentistry, certain factors affect the performance of the proposed approaches, including limited data availability, imbalanced classes, and lack of transparency and interpretability. Hence, it is of utmost importance for the research community to formulate suitable approaches, considering the existing challenges and leveraging findings from the existing studies. Based on an extensive literature review, this survey provides a brief overview of X-ray and near-infrared imaging systems. Additionally, a comprehensive insight into challenges faced by researchers in the dental domain has been brought forth in this survey. The article further offers an amalgamative assessment of both performances and methods evaluated on public benchmarks and concludes with ethical considerations and future research avenues. Shafi, Imran; Fatima, Anum; Afzal, Hammad; Díez, Isabel de la Torre; Lipari, Vivian; Breñosa, Jose y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, josemanuel.brenosa@uneatlantico.es, SIN ESPECIFICAR
A Comprehensive Review of Recent Advances in Artificial Intelligence for Dentistry E-Health.
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Background and Aims The 2022-mpox outbreak has spread worldwide in a short time. Integrated knowledge of the epidemiology, clinical characteristics, and transmission of mpox are limited. This systematic review of peer-reviewed articles and gray literature was conducted to shed light on the epidemiology, clinical features, and transmission of 2022-mpox outbreak. Methods We identified 45 peer-reviewed manuscripts for data analysis. The standards of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement and Cochrane Collaboration were followed for conducting the study. Results The case number of mpox has increased about 100 times worldwide. About 99% of the cases in 2022 outbreak was from non-endemic regions. Men (70%–98% cases) were mostly infected with homosexual and bisexual behavior (30%–60%). The ages of the infected people ranged between 30 and 40 years. The presence of HIV and sexually transmitted infections among 30%–60% of cases were reported. Human-to-human transmission via direct contact and different body fluids were involved in the majority of the cases (90%–100%). Lesions in genitals, perianal, and anogenital areas were more prevalent. Unusually, pharyngitis (15%–40%) and proctitis (20%–40%) were more common during 2022 outbreak than pre-2022 outbreaks. Brincidofovir is approved for the treatment of smallpox by FDA (USA). Two vaccines, including JYNNEOSTM and ACAM2000®, are approved and used for pre- and post-prophylaxis in cases. About 100% of the cases in non-endemic regions were associated with isolates of IIb clade with a divergence of 0.0018–0.0035. Isolates from B.1 lineage were the most predominant followed by B.1.2 and B.1.10. Conclusion This study will add integrated knowledge of the epidemiology, clinical features, and transmission of mpox. Sharif, Nadim; Sharif, Nazmul; Alzahrani, Khalid J.; Halawani, Ibrahim F.; Alzahrani, Fuad M.; Díez, Isabel De la Torre; Lipari, Vivian; López Flores, Miguel Ángel; Parvez, Anowar K. y Dey, Shuvra K. SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, miguelangel.lopez@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Background and Aims The 2022-mpox outbreak has spread worldwide in a short time. Integrated knowledge of the epidemiology, clinical characteristics, and transmission of mpox are limited. This systematic review of peer-reviewed articles and gray literature was conducted to shed light on the epidemiology, clinical features, and transmission of 2022-mpox outbreak. Methods We identified 45 peer-reviewed manuscripts for data analysis. The standards of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement and Cochrane Collaboration were followed for conducting the study. Results The case number of mpox has increased about 100 times worldwide. About 99% of the cases in 2022 outbreak was from non-endemic regions. Men (70%–98% cases) were mostly infected with homosexual and bisexual behavior (30%–60%). The ages of the infected people ranged between 30 and 40 years. The presence of HIV and sexually transmitted infections among 30%–60% of cases were reported. Human-to-human transmission via direct contact and different body fluids were involved in the majority of the cases (90%–100%). Lesions in genitals, perianal, and anogenital areas were more prevalent. Unusually, pharyngitis (15%–40%) and proctitis (20%–40%) were more common during 2022 outbreak than pre-2022 outbreaks. Brincidofovir is approved for the treatment of smallpox by FDA (USA). Two vaccines, including JYNNEOSTM and ACAM2000®, are approved and used for pre- and post-prophylaxis in cases. About 100% of the cases in non-endemic regions were associated with isolates of IIb clade with a divergence of 0.0018–0.0035. Isolates from B.1 lineage were the most predominant followed by B.1.2 and B.1.10. Conclusion This study will add integrated knowledge of the epidemiology, clinical features, and transmission of mpox. Sharif, Nadim; Sharif, Nazmul; Alzahrani, Khalid J.; Halawani, Ibrahim F.; Alzahrani, Fuad M.; Díez, Isabel De la Torre; Lipari, Vivian; López Flores, Miguel Ángel; Parvez, Anowar K. y Dey, Shuvra K. SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, miguelangel.lopez@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Molecular epidemiology, transmission and clinical features of 2022‐mpox outbreak: A systematic review.
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Objective The aim was to explore the association of demographic and prehospital parameters with short-term and long-term mortality in acute life-threatening cardiovascular disease by using a hazard model, focusing on elderly individuals, by comparing patients under 75 years versus patients over 75 years of age. Design Prospective, multicentre, observational study. Setting Emergency medical services (EMS) delivery study gathering data from two back-to-back studies between 1 October 2019 and 30 November 2021. Six advanced life support (ALS), 43 basic life support and five hospitals in Spain were considered. Participants Adult patients suffering from acute life-threatening cardiovascular disease attended by the EMS. Primary and secondary outcome measures The primary outcome was in-hospital mortality from any cause within the first to the 365 days following EMS attendance. The main measures included prehospital demographics, biochemical variables, prehospital ALS techniques used and syndromic suspected conditions. Results A total of 1744 patients fulfilled the inclusion criteria. The 365-day cumulative mortality in the elderly amounted to 26.1% (229 cases) versus 11.6% (11.6%) in patients under 75 years old. Elderly patients (≥75 years) presented a twofold risk of mortality compared with patients ≤74 years. Life-threatening interventions (mechanical ventilation, cardioversion and defibrillation) were also related to a twofold increased risk of mortality. Importantly, patients suffering from acute heart failure presented a more than twofold increased risk of mortality. Conclusions This study revealed the prehospital variables associated with the long-term mortality of patients suffering from acute cardiovascular disease. Our results provide important insights for the development of specific codes or scores for cardiovascular diseases to facilitate the risk of mortality characterisation. del Pozo Vegas, Carlos; Zalama-Sánchez, Daniel; Sanz-Garcia, Ancor; López-Izquierdo, Raúl; Sáez-Belloso, Silvia; Mazas Pérez-Oleaga, Cristina; Dominguez Azpíroz, Irma; Elío Pascual, Iñaki y Martín-Rodríguez, Francisco SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, irma.dominguez@unini.edu.mx, inaki.elio@uneatlantico.es, SIN ESPECIFICAR
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros
Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Objective The aim was to explore the association of demographic and prehospital parameters with short-term and long-term mortality in acute life-threatening cardiovascular disease by using a hazard model, focusing on elderly individuals, by comparing patients under 75 years versus patients over 75 years of age. Design Prospective, multicentre, observational study. Setting Emergency medical services (EMS) delivery study gathering data from two back-to-back studies between 1 October 2019 and 30 November 2021. Six advanced life support (ALS), 43 basic life support and five hospitals in Spain were considered. Participants Adult patients suffering from acute life-threatening cardiovascular disease attended by the EMS. Primary and secondary outcome measures The primary outcome was in-hospital mortality from any cause within the first to the 365 days following EMS attendance. The main measures included prehospital demographics, biochemical variables, prehospital ALS techniques used and syndromic suspected conditions. Results A total of 1744 patients fulfilled the inclusion criteria. The 365-day cumulative mortality in the elderly amounted to 26.1% (229 cases) versus 11.6% (11.6%) in patients under 75 years old. Elderly patients (≥75 years) presented a twofold risk of mortality compared with patients ≤74 years. Life-threatening interventions (mechanical ventilation, cardioversion and defibrillation) were also related to a twofold increased risk of mortality. Importantly, patients suffering from acute heart failure presented a more than twofold increased risk of mortality. Conclusions This study revealed the prehospital variables associated with the long-term mortality of patients suffering from acute cardiovascular disease. Our results provide important insights for the development of specific codes or scores for cardiovascular diseases to facilitate the risk of mortality characterisation. del Pozo Vegas, Carlos; Zalama-Sánchez, Daniel; Sanz-Garcia, Ancor; López-Izquierdo, Raúl; Sáez-Belloso, Silvia; Mazas Pérez-Oleaga, Cristina; Dominguez Azpíroz, Irma; Elío Pascual, Iñaki y Martín-Rodríguez, Francisco SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, irma.dominguez@unini.edu.mx, inaki.elio@uneatlantico.es, SIN ESPECIFICAR
Prehospital acute life-threatening cardiovascular disease in elderly: an observational, prospective, multicentre, ambulance-based cohort study.
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Background: Nowadays, there is no gold standard score for prehospital sepsis and sepsis-related mortality identification. The aim of the present study was to analyze the performance of qSOFA, NEWS2 and mSOFA as sepsis predictors in patients with infection-suspected in prehospital care. The second objective is to study the predictive ability of the aforementioned scores in septic-shock and in-hospital mortality. Methods: Prospective, ambulance-based, and multicenter cohort study, developed by the emergency medical services, among patients (n = 535) with suspected infection transferred by ambulance with high-priority to the emergency department (ED). The study enrolled 40 ambulances and 4 ED in Spain between 1 January 2020, and 30 September 2021. All the variables used in the scores, in addition to socio-demographic data, standard vital signs, prehospital analytical parameters (glucose, lactate, and creatinine) were collected. For the evaluation of the scores, the discriminative power, calibration curve and decision curve analysis (DCA) were used. Results: The mSOFA outperformed the other two scores for mortality, presenting the following AUCs: 0.877 (95%CI 0.841–0.913), 0.761 (95%CI 0.706–0.816), 0.731 (95%CI 0.674–0.788), for mSOFA, NEWS, and qSOFA, respectively. No differences were found for sepsis nor septic shock, but mSOFA’s AUCs was higher than the one of the other two scores. The calibration curve and DCA presented similar results. Conclusion: The use of mSOFA could provide and extra insight regarding the short-term mortality and sepsis diagnostic, backing its recommendation in the prehospital scenario. Melero-Guijarro, Laura; Sanz-García, Ancor; Martín-Rodríguez, Francisco; Lipari, Vivian; Mazas Pérez-Oleaga, Cristina; Carvajal-Altamiranda, Stefanía; Martínez López, Nohora Milena; Dominguez Azpíroz, Irma; Castro Villamor, Miguel A.; Sánchez Soberón, Irene y López-Izquierdo, Raúl SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, cristina.mazas@uneatlantico.es, stefania.carvajal@uneatlantico.es, nohora.martinez@uneatlantico.es, irma.dominguez@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Background: Nowadays, there is no gold standard score for prehospital sepsis and sepsis-related mortality identification. The aim of the present study was to analyze the performance of qSOFA, NEWS2 and mSOFA as sepsis predictors in patients with infection-suspected in prehospital care. The second objective is to study the predictive ability of the aforementioned scores in septic-shock and in-hospital mortality. Methods: Prospective, ambulance-based, and multicenter cohort study, developed by the emergency medical services, among patients (n = 535) with suspected infection transferred by ambulance with high-priority to the emergency department (ED). The study enrolled 40 ambulances and 4 ED in Spain between 1 January 2020, and 30 September 2021. All the variables used in the scores, in addition to socio-demographic data, standard vital signs, prehospital analytical parameters (glucose, lactate, and creatinine) were collected. For the evaluation of the scores, the discriminative power, calibration curve and decision curve analysis (DCA) were used. Results: The mSOFA outperformed the other two scores for mortality, presenting the following AUCs: 0.877 (95%CI 0.841–0.913), 0.761 (95%CI 0.706–0.816), 0.731 (95%CI 0.674–0.788), for mSOFA, NEWS, and qSOFA, respectively. No differences were found for sepsis nor septic shock, but mSOFA’s AUCs was higher than the one of the other two scores. The calibration curve and DCA presented similar results. Conclusion: The use of mSOFA could provide and extra insight regarding the short-term mortality and sepsis diagnostic, backing its recommendation in the prehospital scenario. Melero-Guijarro, Laura; Sanz-García, Ancor; Martín-Rodríguez, Francisco; Lipari, Vivian; Mazas Pérez-Oleaga, Cristina; Carvajal-Altamiranda, Stefanía; Martínez López, Nohora Milena; Dominguez Azpíroz, Irma; Castro Villamor, Miguel A.; Sánchez Soberón, Irene y López-Izquierdo, Raúl SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, cristina.mazas@uneatlantico.es, stefania.carvajal@uneatlantico.es, nohora.martinez@uneatlantico.es, irma.dominguez@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR
Prehospital qSOFA, mSOFA, and NEWS2 performance for sepsis prediction: A prospective, multi-center, cohort study.
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Introduction: Co-prevalence of long-COVID-19, cardiovascular diseases and diabetes is one of the major health challenges of the pandemic worldwide. Studies on long-COVID-19 and associated health outcomes are absent in Bangladesh. The main aim of this study was to determine the prevalence and impact of long-COVID-19 on preexisting diabetes and cardiovascular diseases (CVD) on health outcomes among patients in Bangladesh. Methods: We collected data from 3,250 participants in Bangladesh, retrospectively. Multivariable logistic regression model was used to determine the odds ratio between independent and dependent variables. Kaplan-Meier survival curve was used to determine the cumulative survival. Results: COVID-19 was detected among 73.4% (2,385 of 3,250) participants. Acute long-COVID-19 was detected among 28.4% (678 of 2,385) and chronic long-COVID-19 among 71.6% (1,707 of 2,385) patients. CVD and diabetes were found among 32%, and 24% patients, respectively. Mortality rate was 18% (585 of 3,250) among the participants. Co-prevalence of CVD, diabetes and COVID-19 was involved in majority of fatality (95%). Fever (97%), dry cough (87%) and loss of taste and smell (85%) were the most prevalent symptoms. Patients with co-prevalence of CVD, diabetes and COVID-19 had higher risk of fatality (OR: 3.65, 95% CI, 2.79–4.24). Co-prevalence of CVD, diabetes and chronic long-COVID-19 were detected among 11.9% patients. Discussion: Risk of hospitalization and fatality reduced significantly among the vaccinated. This is one of the early studies on long-COVID-19 in Bangladesh. Sharif, Nadim; Sharif, Nazmul; Khan, Afsana; Halawani, Ibrahim F.; Alzahrani, Fuad M.; Alzahrani, Khalid J.; Díez, Isabel De la Torre; Ramírez-Vargas, Debora L.; Kuc Castilla, Ángel Gabriel; Parvez, Anowar Khasru y Dey, Shuvra Kanti SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, debora.ramirez@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Introduction: Co-prevalence of long-COVID-19, cardiovascular diseases and diabetes is one of the major health challenges of the pandemic worldwide. Studies on long-COVID-19 and associated health outcomes are absent in Bangladesh. The main aim of this study was to determine the prevalence and impact of long-COVID-19 on preexisting diabetes and cardiovascular diseases (CVD) on health outcomes among patients in Bangladesh. Methods: We collected data from 3,250 participants in Bangladesh, retrospectively. Multivariable logistic regression model was used to determine the odds ratio between independent and dependent variables. Kaplan-Meier survival curve was used to determine the cumulative survival. Results: COVID-19 was detected among 73.4% (2,385 of 3,250) participants. Acute long-COVID-19 was detected among 28.4% (678 of 2,385) and chronic long-COVID-19 among 71.6% (1,707 of 2,385) patients. CVD and diabetes were found among 32%, and 24% patients, respectively. Mortality rate was 18% (585 of 3,250) among the participants. Co-prevalence of CVD, diabetes and COVID-19 was involved in majority of fatality (95%). Fever (97%), dry cough (87%) and loss of taste and smell (85%) were the most prevalent symptoms. Patients with co-prevalence of CVD, diabetes and COVID-19 had higher risk of fatality (OR: 3.65, 95% CI, 2.79–4.24). Co-prevalence of CVD, diabetes and chronic long-COVID-19 were detected among 11.9% patients. Discussion: Risk of hospitalization and fatality reduced significantly among the vaccinated. This is one of the early studies on long-COVID-19 in Bangladesh. Sharif, Nadim; Sharif, Nazmul; Khan, Afsana; Halawani, Ibrahim F.; Alzahrani, Fuad M.; Alzahrani, Khalid J.; Díez, Isabel De la Torre; Ramírez-Vargas, Debora L.; Kuc Castilla, Ángel Gabriel; Parvez, Anowar Khasru y Dey, Shuvra Kanti SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, debora.ramirez@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR
Prevalence and impact of long COVID-19 among patients with diabetes and cardiovascular diseases in Bangladesh.
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Mutations allow viruses to continuously evolve by changing their genetic code to adapt to the hosts they infect. It is an adaptive and evolutionary mechanism that helps viruses acquire characteristics favoring their survival and propagation. The COVID-19 pandemic declared by the WHO in March 2020 is caused by the SARS-CoV-2 virus. The non-stop adaptive mutations of this virus and the emergence of several variants over time with characteristics favoring their spread constitute one of the biggest obstacles that researchers face in controlling this pandemic. Understanding the mutation mechanism allows for the adoption of anticipatory measures and the proposal of strategies to control its propagation. In this study, we focus on the mutations of this virus, and we propose the SARSMutOnto ontology to model SARS-CoV-2 mutations reported by Pango researchers. A detailed description is given for each mutation. The genes where the mutations occur and the genomic structure of this virus are also included. The sub-lineages and the recombinant sub-lineages resulting from these mutations are additionally represented while maintaining their hierarchy. We developed a Python-based tool to automatically generate this ontology from various published Pango source files. At the end of this paper, we provide some examples of SPARQL queries that can be used to exploit this ontology. SARSMutOnto might become a ‘wet bench’ machine learning tool for predicting likely future mutations based on previous mutations. Bakkas, Jamal; Hanine, Mohamed; Chekry, Abderrahman; Gounane, Said; de la Torre Díez, Isabel; Lipari, Vivian; Martínez López, Nohora Milena y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, nohora.martinez@uneatlantico.es, SIN ESPECIFICAR
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Mutations allow viruses to continuously evolve by changing their genetic code to adapt to the hosts they infect. It is an adaptive and evolutionary mechanism that helps viruses acquire characteristics favoring their survival and propagation. The COVID-19 pandemic declared by the WHO in March 2020 is caused by the SARS-CoV-2 virus. The non-stop adaptive mutations of this virus and the emergence of several variants over time with characteristics favoring their spread constitute one of the biggest obstacles that researchers face in controlling this pandemic. Understanding the mutation mechanism allows for the adoption of anticipatory measures and the proposal of strategies to control its propagation. In this study, we focus on the mutations of this virus, and we propose the SARSMutOnto ontology to model SARS-CoV-2 mutations reported by Pango researchers. A detailed description is given for each mutation. The genes where the mutations occur and the genomic structure of this virus are also included. The sub-lineages and the recombinant sub-lineages resulting from these mutations are additionally represented while maintaining their hierarchy. We developed a Python-based tool to automatically generate this ontology from various published Pango source files. At the end of this paper, we provide some examples of SPARQL queries that can be used to exploit this ontology. SARSMutOnto might become a ‘wet bench’ machine learning tool for predicting likely future mutations based on previous mutations. Bakkas, Jamal; Hanine, Mohamed; Chekry, Abderrahman; Gounane, Said; de la Torre Díez, Isabel; Lipari, Vivian; Martínez López, Nohora Milena y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, vivian.lipari@uneatlantico.es, nohora.martinez@uneatlantico.es, SIN ESPECIFICAR
SARSMutOnto: An Ontology for SARS-CoV-2 Lineages and Mutations.
Artículo
Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés This study sought to investigate how different brain regions are affected by Alzheimer’s disease (AD) at various phases of the disease, using independent component analysis (ICA). The study examines six regions in the mild cognitive impairment (MCI) stage, four in the early stage of Alzheimer’s disease (AD), six in the moderate stage, and six in the severe stage. The precuneus, cuneus, middle frontal gyri, calcarine cortex, superior medial frontal gyri, and superior frontal gyri were the areas impacted at all phases. A general linear model (GLM) is used to extract the voxels of the previously mentioned regions. The resting fMRI data for 18 AD patients who had advanced from MCI to stage 3 of the disease were obtained from the ADNI public source database. The subjects include eight women and ten men. The voxel dataset is used to train and test ten machine learning algorithms to categorize the MCI, mild, moderate, and severe stages of Alzheimer’s disease. The accuracy, recall, precision, and F1 score were used as conventional scoring measures to evaluate the classification outcomes. AdaBoost fared better than the other algorithms and obtained a phenomenal accuracy of 98.61%, precision of 99.00%, and recall and F1 scores of 98.00% each. Shahzadi, Samra; Butt, Naveed Anwer; Sana, Muhammad Usman; Elío Pascual, Iñaki; Briones Urbano, Mercedes; Díez, Isabel de la Torre y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, inaki.elio@uneatlantico.es, mercedes.briones@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés This study sought to investigate how different brain regions are affected by Alzheimer’s disease (AD) at various phases of the disease, using independent component analysis (ICA). The study examines six regions in the mild cognitive impairment (MCI) stage, four in the early stage of Alzheimer’s disease (AD), six in the moderate stage, and six in the severe stage. The precuneus, cuneus, middle frontal gyri, calcarine cortex, superior medial frontal gyri, and superior frontal gyri were the areas impacted at all phases. A general linear model (GLM) is used to extract the voxels of the previously mentioned regions. The resting fMRI data for 18 AD patients who had advanced from MCI to stage 3 of the disease were obtained from the ADNI public source database. The subjects include eight women and ten men. The voxel dataset is used to train and test ten machine learning algorithms to categorize the MCI, mild, moderate, and severe stages of Alzheimer’s disease. The accuracy, recall, precision, and F1 score were used as conventional scoring measures to evaluate the classification outcomes. AdaBoost fared better than the other algorithms and obtained a phenomenal accuracy of 98.61%, precision of 99.00%, and recall and F1 scores of 98.00% each. Shahzadi, Samra; Butt, Naveed Anwer; Sana, Muhammad Usman; Elío Pascual, Iñaki; Briones Urbano, Mercedes; Díez, Isabel de la Torre y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, inaki.elio@uneatlantico.es, mercedes.briones@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR
Voxel Extraction and Multiclass Classification of Identified Brain Regions across Various Stages of Alzheimer’s Disease Using Machine Learning Approaches.
Artículo
Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Objective This study aims to develop a lightweight convolutional neural network-based edge federated learning architecture for COVID-19 detection using X-ray images, aiming to minimize computational cost, latency, and bandwidth requirements while preserving patient privacy. Method The proposed method uses an edge federated learning architecture to optimize task allocation and execution. Unlike in traditional edge networks where requests from fixed nodes are handled by nearby edge devices or remote clouds, the proposed model uses an intelligent broker within the federation to assess member edge cloudlets' parameters, such as resources and hop count, to make optimal decisions for task offloading. This approach enhances performance and privacy by placing tasks in closer proximity to the user. DenseNet is used for model training, with a depth of 60 and 357,482 parameters. This resource-aware distributed approach optimizes computing resource utilization within the edge-federated learning architecture. Results The experimental results demonstrate significant improvements in various performance metrics. The proposed method reduces training time by 53.1%, optimizes CPU and memory utilization by 17.5% and 33.6%, and maintains accurate COVID-19 detection capabilities without compromising the F1 score, demonstrating the efficiency and effectiveness of the lightweight convolutional neural network-based edge federated learning architecture. Conclusion Existing studies predominantly concentrate on either privacy and accuracy or load balancing and energy optimization, with limited emphasis on training time. The proposed approach offers a comprehensive performance-centric solution that simultaneously addresses privacy, load balancing, and energy optimization while reducing training time, providing a more holistic and balanced solution for optimal system performance. Alvi, Sohaib Bin Khalid; Nayyer, Muhammad Ziad; Jamal, Muhammad Hasan; Raza, Imran; de la Torre Diez, Isabel; Rodríguez Velasco, Carmen Lilí; Breñosa, Jose y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, carmen.rodriguez@uneatlantico.es, josemanuel.brenosa@uneatlantico.es, SIN ESPECIFICAR
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Objective This study aims to develop a lightweight convolutional neural network-based edge federated learning architecture for COVID-19 detection using X-ray images, aiming to minimize computational cost, latency, and bandwidth requirements while preserving patient privacy. Method The proposed method uses an edge federated learning architecture to optimize task allocation and execution. Unlike in traditional edge networks where requests from fixed nodes are handled by nearby edge devices or remote clouds, the proposed model uses an intelligent broker within the federation to assess member edge cloudlets' parameters, such as resources and hop count, to make optimal decisions for task offloading. This approach enhances performance and privacy by placing tasks in closer proximity to the user. DenseNet is used for model training, with a depth of 60 and 357,482 parameters. This resource-aware distributed approach optimizes computing resource utilization within the edge-federated learning architecture. Results The experimental results demonstrate significant improvements in various performance metrics. The proposed method reduces training time by 53.1%, optimizes CPU and memory utilization by 17.5% and 33.6%, and maintains accurate COVID-19 detection capabilities without compromising the F1 score, demonstrating the efficiency and effectiveness of the lightweight convolutional neural network-based edge federated learning architecture. Conclusion Existing studies predominantly concentrate on either privacy and accuracy or load balancing and energy optimization, with limited emphasis on training time. The proposed approach offers a comprehensive performance-centric solution that simultaneously addresses privacy, load balancing, and energy optimization while reducing training time, providing a more holistic and balanced solution for optimal system performance. Alvi, Sohaib Bin Khalid; Nayyer, Muhammad Ziad; Jamal, Muhammad Hasan; Raza, Imran; de la Torre Diez, Isabel; Rodríguez Velasco, Carmen Lilí; Breñosa, Jose y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, carmen.rodriguez@uneatlantico.es, josemanuel.brenosa@uneatlantico.es, SIN ESPECIFICAR
A lightweight deep learning approach for COVID-19 detection using X-ray images with edge federation.
2022
Artículo
Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Artificial intelligence has been widely used in the field of dentistry in recent years. The present study highlights current advances and limitations in integrating artificial intelligence, machine learning, and deep learning in subfields of dentistry including periodontology, endodontics, orthodontics, restorative dentistry, and oral pathology. This article aims to provide a systematic review of current clinical applications of artificial intelligence within different fields of dentistry. The preferred reporting items for systematic reviews (PRISMA) statement was used as a formal guideline for data collection. Data was obtained from research studies for 2009–2022. The analysis included a total of 55 papers from Google Scholar, IEEE, PubMed, and Scopus databases. Results show that artificial intelligence has the potential to improve dental care, disease diagnosis and prognosis, treatment planning, and risk assessment. Finally, this study highlights the limitations of the analyzed studies and provides future directions to improve dental care Fatima, Anum; Shafi, Imran; Afzal, Hammad; Díez, Isabel De La Torre; Lourdes, Del Rio-Solá M.; Breñosa, Jose; Martínez Espinosa, Julio César y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, josemanuel.brenosa@uneatlantico.es, ulio.martinez@unini.edu.mx, SIN ESPECIFICAR
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Artificial intelligence has been widely used in the field of dentistry in recent years. The present study highlights current advances and limitations in integrating artificial intelligence, machine learning, and deep learning in subfields of dentistry including periodontology, endodontics, orthodontics, restorative dentistry, and oral pathology. This article aims to provide a systematic review of current clinical applications of artificial intelligence within different fields of dentistry. The preferred reporting items for systematic reviews (PRISMA) statement was used as a formal guideline for data collection. Data was obtained from research studies for 2009–2022. The analysis included a total of 55 papers from Google Scholar, IEEE, PubMed, and Scopus databases. Results show that artificial intelligence has the potential to improve dental care, disease diagnosis and prognosis, treatment planning, and risk assessment. Finally, this study highlights the limitations of the analyzed studies and provides future directions to improve dental care Fatima, Anum; Shafi, Imran; Afzal, Hammad; Díez, Isabel De La Torre; Lourdes, Del Rio-Solá M.; Breñosa, Jose; Martínez Espinosa, Julio César y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, josemanuel.brenosa@uneatlantico.es, ulio.martinez@unini.edu.mx, SIN ESPECIFICAR
Advancements in Dentistry with Artificial Intelligence: Current Clinical Applications and Future Perspectives.
Artículo
Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Español Patient care and convenience remain the concern of medical professionals and caregivers alike. An unconscious patient confined to a bed may develop fluid accumulation and pressure sores due to inactivity and deficiency of oxygen flow. Moreover, weight monitoring is crucial for an effective treatment plan, which is difficult to measure for bedridden patients. This paper presents the design and development of a smart and cost-effective independent system for lateral rotation, movement, weight measurement, and transporting immobile patients. Optimal dimensions and practical design specifications are determined by a survey across various hospitals. Subsequently, the proposed hoist-based weighing and turning mechanism is CAD-modeled and simulated. Later, the structural analysis is carried out to select suitable metallurgy for various sub-assemblies to ensure design reliability. After fabrication, optimization, integration, and testing procedures, the base frame is designed to mount a hydraulic motor for the actuator, a DC power source for self-sustenance, and lockable wheels for portability. The installation of a weighing scale and a hydraulic actuator is ensured to lift the patient for weight measuring up to 600 pounds or lateral turning of 80 degrees both ways. The developed system offers simple operating characteristics, allows for keeping patient weight records, and assists nurses in changing patients’ lateral positions both ways, comfortably massage patients’ backs, and transport them from one bed to another. Additionally, being lightweight offers reduced contact with the patient to increase the healthcare staff’s safety in pandemics; it is also height adjustable and portable, allowing for use with multiple-sized beds and easy transportation across the medical facility. The feedback from paramedics is encouraging regarding reducing labor-intensive nursing tasks, alleviating the discomfort of long-term bed-ridden patients, and allowing medical practitioners to suggest better treatment plans Shafi, Imran; Farooq, Muhammad Siddique; De La Torre Díez, Isabel; Breñosa, Jose; Martínez Espinosa, Julio César y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, josemanuel.brenosa@uneatlantico.es, ulio.martinez@unini.edu.mx, SIN ESPECIFICAR
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Español Patient care and convenience remain the concern of medical professionals and caregivers alike. An unconscious patient confined to a bed may develop fluid accumulation and pressure sores due to inactivity and deficiency of oxygen flow. Moreover, weight monitoring is crucial for an effective treatment plan, which is difficult to measure for bedridden patients. This paper presents the design and development of a smart and cost-effective independent system for lateral rotation, movement, weight measurement, and transporting immobile patients. Optimal dimensions and practical design specifications are determined by a survey across various hospitals. Subsequently, the proposed hoist-based weighing and turning mechanism is CAD-modeled and simulated. Later, the structural analysis is carried out to select suitable metallurgy for various sub-assemblies to ensure design reliability. After fabrication, optimization, integration, and testing procedures, the base frame is designed to mount a hydraulic motor for the actuator, a DC power source for self-sustenance, and lockable wheels for portability. The installation of a weighing scale and a hydraulic actuator is ensured to lift the patient for weight measuring up to 600 pounds or lateral turning of 80 degrees both ways. The developed system offers simple operating characteristics, allows for keeping patient weight records, and assists nurses in changing patients’ lateral positions both ways, comfortably massage patients’ backs, and transport them from one bed to another. Additionally, being lightweight offers reduced contact with the patient to increase the healthcare staff’s safety in pandemics; it is also height adjustable and portable, allowing for use with multiple-sized beds and easy transportation across the medical facility. The feedback from paramedics is encouraging regarding reducing labor-intensive nursing tasks, alleviating the discomfort of long-term bed-ridden patients, and allowing medical practitioners to suggest better treatment plans Shafi, Imran; Farooq, Muhammad Siddique; De La Torre Díez, Isabel; Breñosa, Jose; Martínez Espinosa, Julio César y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, josemanuel.brenosa@uneatlantico.es, ulio.martinez@unini.edu.mx, SIN ESPECIFICAR
Design and Development of Smart Weight Measurement, Lateral Turning and Transfer Bedding for Unconscious Patients in Pandemics.
Artículo
Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés The diagnosis of early-stage lung cancer is challenging due to its asymptomatic nature, especially given the repeated radiation exposure and high cost of computed tomography(CT). Examining the lung CT images to detect pulmonary nodules, especially the cell lung cancer lesions, is also tedious and prone to errors even by a specialist. This study proposes a cancer diagnostic model based on a deep learning-enabled support vector machine (SVM). The proposed computer-aided design (CAD) model identifies the physiological and pathological changes in the soft tissues of the cross-section in lung cancer lesions. The model is first trained to recognize lung cancer by measuring and comparing the selected profile values in CT images obtained from patients and control patients at their diagnosis. Then, the model is tested and validated using the CT scans of both patients and control patients that are not shown in the training phase. The study investigates 888 annotated CT scans from the publicly available LIDC/IDRI database. The proposed deep learning-assisted SVM-based model yields 94% accuracy for pulmonary nodule detection representing early-stage lung cancer. It is found superior to other existing methods including complex deep learning, simple machine learning, and the hybrid techniques used on lung CT images for nodule detection. Experimental results demonstrate that the proposed approach can greatly assist radiologists in detecting early lung cancer and facilitating the timely management of patients. Shafi, Imran; Din, Sadia; Khan, Asim; Díez, Isabel De La Torre; Pali-Casanova, Ramón; Tutusaus, Kilian y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, ramon.pali@unini.edu.mx, kilian.tutusaus@uneatlantico.es, SIN ESPECIFICAR
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés The diagnosis of early-stage lung cancer is challenging due to its asymptomatic nature, especially given the repeated radiation exposure and high cost of computed tomography(CT). Examining the lung CT images to detect pulmonary nodules, especially the cell lung cancer lesions, is also tedious and prone to errors even by a specialist. This study proposes a cancer diagnostic model based on a deep learning-enabled support vector machine (SVM). The proposed computer-aided design (CAD) model identifies the physiological and pathological changes in the soft tissues of the cross-section in lung cancer lesions. The model is first trained to recognize lung cancer by measuring and comparing the selected profile values in CT images obtained from patients and control patients at their diagnosis. Then, the model is tested and validated using the CT scans of both patients and control patients that are not shown in the training phase. The study investigates 888 annotated CT scans from the publicly available LIDC/IDRI database. The proposed deep learning-assisted SVM-based model yields 94% accuracy for pulmonary nodule detection representing early-stage lung cancer. It is found superior to other existing methods including complex deep learning, simple machine learning, and the hybrid techniques used on lung CT images for nodule detection. Experimental results demonstrate that the proposed approach can greatly assist radiologists in detecting early lung cancer and facilitating the timely management of patients. Shafi, Imran; Din, Sadia; Khan, Asim; Díez, Isabel De La Torre; Pali-Casanova, Ramón; Tutusaus, Kilian y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, ramon.pali@unini.edu.mx, kilian.tutusaus@uneatlantico.es, SIN ESPECIFICAR
An Effective Method for Lung Cancer Diagnosis from CT Scan Using Deep Learning-Based Support Vector Network.
Artículo
Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Mobility and low energy consumption are considered the main requirements for wireless body area sensor networks (WBASN) used in healthcare monitoring systems (HMS). In HMS, battery-powered sensor nodes with limited energy are used to obtain vital statistics about the body. Hence, energy-efficient schemes are desired to maintain long-term and steady connectivity of the sensor nodes. A sheer amount of energy is consumed in activities such as idle listening, excessive transmission and reception of control messages, packet collisions and retransmission of packets, and poor path selection, that may lead to more energy consumption. A combination of adaptive scheduling with an energy-efficient protocol can help select an appropriate path at a suitable time to minimize the control overhead, energy consumption, packet collision, and excessive idle listening. This paper proposes a region-based energy-efficient multipath routing (REMR) approach that divides the entire sensor network into clusters with preferably multiple candidates to represent each cluster. The cluster representatives (CRs) route packets through various clusters. For routing, the energy requirement of each route is considered, and the path with minimum energy requirements is selected. Similarly, end-to-end delay, higher throughput, and packet-delivery ratio are considered for packet routing. Akbar, Shuja; Mehdi, Muhammad Mohsin; Jamal, M. Hasan; Raza, Imran; Hussain, Syed Asad; Breñosa, Jose; Martínez Espinosa, Julio César; Pascual Barrera, Alina Eugenia y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, josemanuel.brenosa@uneatlantico.es, ulio.martinez@unini.edu.mx, alina.pascual@unini.edu.mx, SIN ESPECIFICAR
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Abierto Inglés Mobility and low energy consumption are considered the main requirements for wireless body area sensor networks (WBASN) used in healthcare monitoring systems (HMS). In HMS, battery-powered sensor nodes with limited energy are used to obtain vital statistics about the body. Hence, energy-efficient schemes are desired to maintain long-term and steady connectivity of the sensor nodes. A sheer amount of energy is consumed in activities such as idle listening, excessive transmission and reception of control messages, packet collisions and retransmission of packets, and poor path selection, that may lead to more energy consumption. A combination of adaptive scheduling with an energy-efficient protocol can help select an appropriate path at a suitable time to minimize the control overhead, energy consumption, packet collision, and excessive idle listening. This paper proposes a region-based energy-efficient multipath routing (REMR) approach that divides the entire sensor network into clusters with preferably multiple candidates to represent each cluster. The cluster representatives (CRs) route packets through various clusters. For routing, the energy requirement of each route is considered, and the path with minimum energy requirements is selected. Similarly, end-to-end delay, higher throughput, and packet-delivery ratio are considered for packet routing. Akbar, Shuja; Mehdi, Muhammad Mohsin; Jamal, M. Hasan; Raza, Imran; Hussain, Syed Asad; Breñosa, Jose; Martínez Espinosa, Julio César; Pascual Barrera, Alina Eugenia y Ashraf, Imran SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, josemanuel.brenosa@uneatlantico.es, ulio.martinez@unini.edu.mx, alina.pascual@unini.edu.mx, SIN ESPECIFICAR
Multipath Routing in Wireless Body Area Sensor Network for Healthcare Monitoring.
Artículo
Materias > Biomedicina
Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Cerrado Inglés Cactus has been used in traditional folk medicine because of its role in treating a number of diseases and conditions. Prickly pear fruit is an excellent source of secondary metabolites (i.e., betalains, flavonoids, and ascorbic acid) with health-promoting properties against many common human diseases, including diabetes, hypertension, hypercholesterolemia, rheumatic pain, gastric mucosa diseases and asthma. In addition, prickly pears are potential candidates for the development of low-cost functional foods because they grow with low water requirements in arid regions of the world. This review describes the main bioactive compounds found in this fruit and shows the in vitro and some clinical studies about the fruit of most important cactus (Opuntia ficus-indica) and its relationship with some chronic diseases. Even though a lot of effort have been done to study the relationship between this fruit and the human health, more studies on Opuntia ficus-indica could help better understand its pharmacological mechanism of action to provide clear scientific evidence to explain its traditional uses, and to identify its therapeutic potential in other diseases. Armas Diaz, Yasmany; Machì, Michele; Salinari, Alessia; Mazas Pérez-Oleaga, Cristina; Martínez López, Nohora Milena; Briones Urbano, Mercedes y Cianciosi, Danila SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, SIN ESPECIFICAR
Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Artículos y libros
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Artículos y libros
Universidad Internacional do Cuanza > Investigación > Artículos y libros Cerrado Inglés Cactus has been used in traditional folk medicine because of its role in treating a number of diseases and conditions. Prickly pear fruit is an excellent source of secondary metabolites (i.e., betalains, flavonoids, and ascorbic acid) with health-promoting properties against many common human diseases, including diabetes, hypertension, hypercholesterolemia, rheumatic pain, gastric mucosa diseases and asthma. In addition, prickly pears are potential candidates for the development of low-cost functional foods because they grow with low water requirements in arid regions of the world. This review describes the main bioactive compounds found in this fruit and shows the in vitro and some clinical studies about the fruit of most important cactus (Opuntia ficus-indica) and its relationship with some chronic diseases. Even though a lot of effort have been done to study the relationship between this fruit and the human health, more studies on Opuntia ficus-indica could help better understand its pharmacological mechanism of action to provide clear scientific evidence to explain its traditional uses, and to identify its therapeutic potential in other diseases. Armas Diaz, Yasmany; Machì, Michele; Salinari, Alessia; Mazas Pérez-Oleaga, Cristina; Martínez López, Nohora Milena; Briones Urbano, Mercedes y Cianciosi, Danila SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, SIN ESPECIFICAR
Prickly pear fruits from "Opuntia ficus-indica" varieties as a source of potential bioactive compounds in the Mediterranean diet.
Este listado fue generado el Wed Jul 15 01:39:02 2026 UTC.