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Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Cerrado Inglés Betalains are water-soluble, nitrogen-containing vacuolar pigment and can be divided into two subclasses: the yellow – orange betaxanthins and the red – violet betacyanin. These pigments can be found mainly in Latin America, but also in some parts of Asia, Africa, Australia and in the Mediterranean area. In this work an overview related with the status of research about betalains extracted from Opuntia spp and the enforces made to evaluate their positive incidence in the human body is provided. Several studies enhance their anticancer, anti-inflammatory and antioxidant properties. They also exhibit antimicrobial and antidiabetic effect. Taking into account these properties, betalains seem to be a promising natural alternative as a colorant to replace the synthetic ones in the food additive industry. In addition, the use of Opuntia spp fruits as possible colorant sources in the Food Industry, may contribute positively to the sustainable development in semi-arid regions. metadata Armas Diaz, Yasmany; Qi, Zexiu; Yang, Bei; Martínez López, Nohora Milena; Briones Urbano, Mercedes y Cianciosi, Danila mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, SIN ESPECIFICAR (2023) Betalains: The main bioactive compounds of Opuntia spp and their possible health benefits in the Mediterranean diet. Mediterranean Journal of Nutrition and Metabolism, 16 (3). pp. 181-190. ISSN 1973798X

Artículo Materias > Biomedicina
Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica Cerrado Inglés Cactus has been used in traditional folk medicine because of its role in treating a number of diseases and conditions. Prickly pear fruit is an excellent source of secondary metabolites (i.e., betalains, flavonoids, and ascorbic acid) with health-promoting properties against many common human diseases, including diabetes, hypertension, hypercholesterolemia, rheumatic pain, gastric mucosa diseases and asthma. In addition, prickly pears are potential candidates for the development of low-cost functional foods because they grow with low water requirements in arid regions of the world. This review describes the main bioactive compounds found in this fruit and shows the in vitro and some clinical studies about the fruit of most important cactus (Opuntia ficus-indica) and its relationship with some chronic diseases. Even though a lot of effort have been done to study the relationship between this fruit and the human health, more studies on Opuntia ficus-indica could help better understand its pharmacological mechanism of action to provide clear scientific evidence to explain its traditional uses, and to identify its therapeutic potential in other diseases. metadata Armas Diaz, Yasmany; Machì, Michele; Salinari, Alessia; Mazas Pérez-Oleaga, Cristina; Martínez López, Nohora Milena; Briones Urbano, Mercedes y Cianciosi, Danila mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, SIN ESPECIFICAR (2022) Prickly pear fruits from "Opuntia ficus-indica" varieties as a source of potential bioactive compounds in the Mediterranean diet. Mediterranean Journal of Nutrition and Metabolism, 15 (4). pp. 581-592. ISSN 1973798X

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Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Cerrado Inglés Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-Fluorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluorouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/β-catenin, Hedgehog and Notch pathways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects. metadata Cianciosi, Danila; Armas Diaz, Yasmany; Alvarez-Suarez, José M.; Chen, Xiumin; Zhang, Di; Martínez López, Nohora Milena; Briones Urbano, Mercedes; Quiles, José L.; Amici, Adolfo; Battino, Maurizio y Giampieri, Francesca mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, jose.quiles@uneatlantico.es, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2023) Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal. Food Chemistry, 427. p. 136684. ISSN 03088146

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Artículo Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Cerrado Inglés Given that it provides nourishment for more than half of humanity, rice is regarded as one of the most significant plants in the world in agriculture. The quantity and quality of the product may be impacted by diseases that can damage rice plants which can occasionally cause crop losses ranging from 30 to 60%. This manuscript proposed a Convolutional Neural Network (CNN) and Visual Geometry Group (VGG)19 i.e. CNN-VGG19 model with a transfer learning-based method for the precise identification and classification of rice leaf diseases. This scheme employs a transfer learning technique based on the VGG19 which can identify the brown spot class. The accuracy is 93.0% in the deployment of the dataset of rice leaf disease. The other parameters are sensitivity, specificity, precision and F1-score with 89.9%, 94.7%, 92.4% and 90.5% respectively. The developed technique obtained better results as compared to the existing baseline models. metadata Dogra, Roopali; Rani, Shalli; Singh, Aman; Albahar, Marwan Ali; Pascual Barrera, Alina Eugenia y Alkhayyat, Ahmed mail SIN ESPECIFICAR, SIN ESPECIFICAR, aman.singh@uneatlantico.es, SIN ESPECIFICAR, alina.pascual@unini.edu.mx, SIN ESPECIFICAR (2023) Deep learning model for detection of brown spot rice leaf disease with smart agriculture. Computers and Electrical Engineering, 109. p. 108659. ISSN 00457906

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Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Cerrado Inglés Diets enriched in plant-based foods are associated with the maintenance of a good well-being and with the prevention of many non-communicable diseases. The health effects of fruits and vegetables consumption are mainly due to the presence of micronutrients, including vitamins and minerals, and polyphenols, plant secondary metabolites. One of the most important classes of phenolic compounds are anthocyanins, that confer the typical purple-red color to many foods, such as berries, peaches, plums, red onions, purple corn, eggplants, as well as purple carrots, sweet potatoes and red cabbages, among others. This commentary aims to briefly highlight the progress made by science in the last years, focusing on some unexpected aspects related with anthocyanins, such as their bioavailability, their health effects and their relationship with gut microbiota metadata Giampieri, Francesca; Cianciosi, Danila; Alvarez-Suarez, José M.; Quiles, José L.; Forbes-Hernández, Tamara Y.; Navarro-Hortal, María D.; Machì, Michele; Pali-Casanova, Ramón; Martínez Espinosa, Julio César; Chen, Xiumin; Zhang, Di; Bai, Weibin; Lingmin, Tian; Mezzetti, Bruno; Battino, Maurizio y Diaz, Yasmany Armas mail francesca.giampieri@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, jose.quiles@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, ramon.pali@unini.edu.mx, ulio.martinez@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR (2023) Anthocyanins: what do we know until now? Journal of Berry Research. pp. 1-6. ISSN 18785093

Artículo Materias > Ciencias Sociales Fundación Universitaria Internacional de Colombia > Investigación > Artículos y libros Cerrado Inglés Introduction The judicialization of health arose following the possibility of judicially demanding the right to health before national and international courts. In the case of Colombia, health litigation is done through a constitutional tool called the tutela action, which allows for the immediate protection of fundamental rights. Methods A retrospective cross-sectional study using a probabilistic stratified sample of 1031 users of the tutela actions, in Medellín, Colombia, between 2011 and 2014. Bivariate and multivariate analyses were performed, using statistical tests and multiple logistic regression models. Results According to the respondents, 95.9% of the tutela actions succeeded in favour of the applicant. On average, the judicial process took 10.96 days (SD = 8.09). After the favourable decision of the tutela action, access to health care followed in 76.2% of cases, partial access was found for 14.0% (median, 10 d), and in 9.8% of cases, claimants had not received access to the health care they sought. Conclusion The tutela action is an essential constitutional mechanism that guarantees the access to health services. However, it must be strengthened from the legal point of view through the implementation of monitoring and control actions and by imposing the sanctioning measures and deadlines established in existing legislation. metadata Gómez‐Ceballos, Diego; Craveiro, Isabel y Gonçalves, Luzia mail SIN ESPECIFICAR (2019) Judicialization of the right to health: (Un)compliance of the judicial decisions in Medellin, Colombia. The International Journal of Health Planning and Management, 34 (4). pp. 1277-1289. ISSN 0749-6753

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Youth Healthy Eating Index (YHEI) and Diet Adequacy in Relation to Country-Specific National Dietary Recommendations in Children and Adolescents in Five Mediterranean Countries from the DELICIOUS Project

Background/Objectives: The diet quality of younger individuals is decreasing globally, with alarming trends also in the Mediterranean region. The aim of this study was to assess diet quality and adequacy in relation to country-specific dietary recommendations for children and adolescents living in the Mediterranean area. Methods: A cross-sectional survey was conducted of 2011 parents of the target population participating in the DELICIOUS EU-PRIMA project. Dietary data and cross-references with food-based recommendations and the application of the youth healthy eating index (YHEI) was assessed through 24 h recalls and food frequency questionnaires. Results: Adherence to recommendations on plant-based foods was low (less than ∼20%), including fruit and vegetables adequacy in all countries, legume adequacy in all countries except for Italy, and cereal adequacy in all countries except for Portugal. For animal products and dietary fats, the adequacy in relation to the national food-based dietary recommendations was slightly better (∼40% on average) in most countries, although the Eastern countries reported worse rates. Higher scores on the YHEI predicted adequacy in relation to vegetables (except Egypt), fruit (except Lebanon), cereals (except Spain), and legumes (except Spain) in most countries. Younger children (p < 0.005) reporting having 8–10 h adequate sleep duration (p < 0.001), <2 h/day screen time (p < 0.001), and a medium/high physical activity level (p < 0.001) displayed a better diet quality. Moreover, older respondents (p < 0.001) with a medium/high educational level (p = 0.001) and living with a partner (p = 0.003) reported that their children had a better diet quality. Conclusions: Plant-based food groups, including fruit, vegetables, legumes, and even (whole-grain) cereals are underrepresented in the diets of Mediterranean children and adolescents. Moreover, the adequate consumption of other important dietary components, such as milk and dairy products, is rather disregarded, leading to substantially suboptimal diets and poor adequacy in relation to dietary guidelines.

Producción Científica

Francesca Giampieri mail francesca.giampieri@uneatlantico.es, Alice Rosi mail , Francesca Scazzina mail , Evelyn Frias-Toral mail , Osama Abdelkarim mail , Mohamed Aly mail , Raynier Zambrano-Villacres mail , Juancho Pons mail , Laura Vázquez-Araújo mail , Sandra Sumalla Cano mail sandra.sumalla@uneatlantico.es, Iñaki Elío Pascual mail inaki.elio@uneatlantico.es, Lorenzo Monasta mail , Ana Mata mail , María Isabel Pardo mail , Pablo Busó mail , Giuseppe Grosso mail ,

Giampieri

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Enhanced interpretable thyroid disease diagnosis by leveraging synthetic oversampling and machine learning models

Thyroid illness encompasses a range of disorders affecting the thyroid gland, leading to either hyperthyroidism or hypothyroidism, which can significantly impact metabolism and overall health. Hypothyroidism can cause a slowdown in bodily processes, leading to symptoms such as fatigue, weight gain, depression, and cold sensitivity. Hyperthyroidism can lead to increased metabolism, causing symptoms like rapid weight loss, anxiety, irritability, and heart palpitations. Prompt diagnosis and appropriate treatment are crucial in managing thyroid disorders and improving patients’ quality of life. Thyroid illness affects millions worldwide and can significantly impact their quality of life if left untreated. This research aims to propose an effective artificial intelligence-based approach for the early diagnosis of thyroid illness. An open-access thyroid disease dataset based on 3,772 male and female patient observations is used for this research experiment. This study uses the nominal continuous synthetic minority oversampling technique (SMOTE-NC) for data balancing and a fine-tuned light gradient booster machine (LGBM) technique to diagnose thyroid illness and handle class imbalance problems. The proposed SNL (SMOTE-NC-LGBM) approach outperformed the state-of-the-art approach with high-accuracy performance scores of 0.96. We have also applied advanced machine learning and deep learning methods for comparison to evaluate performance. Hyperparameter optimizations are also conducted to enhance thyroid diagnosis performance. In addition, we have applied the explainable Artificial Intelligence (XAI) mechanism based on Shapley Additive exPlanations (SHAP) to enhance the transparency and interpretability of the proposed method by analyzing the decision-making processes. The proposed research revolutionizes the diagnosis of thyroid disorders efficiently and helps specialties overcome thyroid disorders early.

Producción Científica

Ali Raza mail , Fatma Eid mail , Elisabeth Caro Montero mail elizabeth.caro@uneatlantico.es, Irene Delgado Noya mail irene.delgado@uneatlantico.es, Imran Ashraf mail ,

Raza

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Performance of the 4C and SEIMC scoring systems in predicting mortality from onset to current COVID-19 pandemic in emergency departments

The evolution of the COVID-19 pandemic has been associated with variations in clinical presentation and severity. Similarly, prediction scores may suffer changes in their diagnostic accuracy. The aim of this study was to test the 30-day mortality predictive validity of the 4C and SEIMC scores during the sixth wave of the pandemic and to compare them with those of validation studies. This was a longitudinal retrospective observational study. COVID-19 patients who were admitted to the Emergency Department of a Spanish hospital from December 15, 2021, to January 31, 2022, were selected. A side-by-side comparison with the pivotal validation studies was subsequently performed. The main measures were 30-day mortality and the 4C and SEIMC scores. A total of 27,614 patients were considered in the study, including 22,361 from the 4C, 4,627 from the SEIMC and 626 from our hospital. The 30-day mortality rate was significantly lower than that reported in the validation studies. The AUCs were 0.931 (95% CI: 0.90–0.95) for 4C and 0.903 (95% CI: 086–0.93) for SEIMC, which were significantly greater than those obtained in the first wave. Despite the changes that have occurred during the coronavirus disease 2019 (COVID-19) pandemic, with a reduction in lethality, scorecard systems are currently still useful tools for detecting patients with poor disease risk, with better prognostic capacity.

Producción Científica

Pedro Ángel de Santos Castro mail , Carlos del Pozo Vegas mail , Leyre Teresa Pinilla Arribas mail , Daniel Zalama Sánchez mail , Ancor Sanz-García mail , Tony Giancarlo Vásquez del Águila mail , Pablo González Izquierdo mail , Sara de Santos Sánchez mail , Cristina Mazas Pérez-Oleaga mail cristina.mazas@uneatlantico.es, Irma Dominguez Azpíroz mail irma.dominguez@unini.edu.mx, Iñaki Elío Pascual mail inaki.elio@uneatlantico.es, Francisco Martín-Rodríguez mail ,

de Santos Castro

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Evolving epidemiology, clinical features, and genotyping of dengue outbreaks in Bangladesh, 2000–2024: a systematic review

Background: The 2023 dengue outbreak has proven that dengue is not only an endemic disease but also an emerging health threat in Bangladesh. Integrated studies on the epidemiology, clinical characteristics, seasonality, and genotype of dengue are limited. This study was conducted to determine recent trends in the molecular epidemiology, clinical features, and seasonality of dengue outbreaks. Methods: We analyzed data from 41 original studies, extracting epidemiological information from all 41 articles, clinical symptoms from 30 articles, and genotypic diversity from 11 articles. The study adhered to the standards of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement and Cochrane Collaboration guidelines. Conclusion: This study provides integrated insights into the molecular epidemiology, clinical features, seasonality, and transmission of dengue in Bangladesh and highlights research gaps for future studies.

Producción Científica

Nadim Sharif mail , Rubayet Rayhan Opu mail , Tama Saha mail , Abdullah Ibna Masud mail , Jannatin Naim mail , Khalaf F. Alsharif mail , Khalid J. Alzahrani mail , Eduardo René Silva Alvarado mail eduardo.silva@funiber.org, Irene Delgado Noya mail irene.delgado@uneatlantico.es, Isabel De la Torre Díez mail , Shuvra Kanti Dey mail ,

Sharif

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Performance of the 4C and SEIMC scoring systems in predicting mortality from onset to current COVID-19 pandemic in emergency departments

Producción Científica

de Santos Castro

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