Judicialization of the right to health: (Un)compliance of the judicial decisions in Medellin, Colombia

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Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal

Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-Fluorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluorouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/β-catenin, Hedgehog and Notch pathways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects.

Producción Científica

Danila Cianciosi mail , Yasmany Armas Diaz mail , José M. Alvarez-Suarez mail , Xiumin Chen mail , Di Zhang mail , Nohora Milena Martínez López mail nohora.martinez@uneatlantico.es, Mercedes Briones Urbano mail mercedes.briones@uneatlantico.es, José L. Quiles mail jose.quiles@uneatlantico.es, Adolfo Amici mail , Maurizio Battino mail maurizio.battino@uneatlantico.es, Francesca Giampieri mail francesca.giampieri@uneatlantico.es,

Cianciosi

<a href="/8725/1/diagnostics-13-02871.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

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Voxel Extraction and Multiclass Classification of Identified Brain Regions across Various Stages of Alzheimer’s Disease Using Machine Learning Approaches

This study sought to investigate how different brain regions are affected by Alzheimer’s disease (AD) at various phases of the disease, using independent component analysis (ICA). The study examines six regions in the mild cognitive impairment (MCI) stage, four in the early stage of Alzheimer’s disease (AD), six in the moderate stage, and six in the severe stage. The precuneus, cuneus, middle frontal gyri, calcarine cortex, superior medial frontal gyri, and superior frontal gyri were the areas impacted at all phases. A general linear model (GLM) is used to extract the voxels of the previously mentioned regions. The resting fMRI data for 18 AD patients who had advanced from MCI to stage 3 of the disease were obtained from the ADNI public source database. The subjects include eight women and ten men. The voxel dataset is used to train and test ten machine learning algorithms to categorize the MCI, mild, moderate, and severe stages of Alzheimer’s disease. The accuracy, recall, precision, and F1 score were used as conventional scoring measures to evaluate the classification outcomes. AdaBoost fared better than the other algorithms and obtained a phenomenal accuracy of 98.61%, precision of 99.00%, and recall and F1 scores of 98.00% each.

Producción Científica

Samra Shahzadi mail , Naveed Anwer Butt mail , Muhammad Usman Sana mail , Iñaki Elío Pascual mail inaki.elio@uneatlantico.es, Mercedes Briones Urbano mail mercedes.briones@uneatlantico.es, Isabel de la Torre Díez mail , Imran Ashraf mail ,

Shahzadi

<a class="ep_document_link" href="/8800/1/Real_Word_Spelling_Error_Detection_and_Correction_for_Urdu_Language.pdf"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

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Real Word Spelling Error Detection and Correction for Urdu Language

Non-word and real-word errors are generally two types of spelling errors. Non-word errors are misspelled words that are nonexistent in the lexicon while real-word errors are misspelled words that exist in the lexicon but are used out of context in a sentence. Lexicon-based lookup approach is widely used for non-word errors but it is incapable of handling real-word errors as they require contextual information. Contrary to the English language, real-word error detection and correction for low-resourced languages like Urdu is an unexplored area. This paper presents a real-word spelling error detection and correction approach for the Urdu language. We develop an extensive lexicon of 593,738 words and use this lexicon to develop a dataset for real-word errors comprising 125562 sentences and 2,552,735 words. Based on the developed lexicon and dataset, we then develop a contextual spell checker that detects and corrects real-word errors. For the real-word error detection phase, word-gram features are used along with five machine learning classifiers, achieving a precision, recall, and F1-score of 0.84,0.79, and 0.81 respectively. We also test the proposed approach with a 40% error density. For real-word error correction, the Damerau-Levenshtein distance is used along with the n-gram model for further ranking of the suggested candidate words, achieving an accuracy of up to 83.67%.

Producción Científica

Romila Aziz mail , Muhammad Waqas Anwar mail , Muhammad Hasan Jamal mail , Usama Ijaz Bajwa mail , Ángel Gabriel Kuc Castilla mail , Carlos Uc-Rios mail carlos.uc@unini.edu.mx, Ernesto Bautista Thompson mail ernesto.bautista@unini.edu.mx, Imran Ashraf mail ,

Aziz

<a class="ep_document_link" href="/8652/1/sensors-23-07018.pdf"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

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Railway Track Fault Detection Using Selective MFCC Features from Acoustic Data

Railway track faults may lead to railway accidents and cause human and financial loss. Spatial, temporal, and weather elements, and wear and tear, lead to ballast, loose nuts, misalignment, and cracks leading to accidents. Manual inspection of such defects is time-consuming and prone to errors. Automatic inspection provides a fast, reliable, and unbiased solution. However, highly accurate fault detection is challenging due to the lack of public datasets, noisy data, inefficient models, etc. To obtain better performance, this study presents a novel approach that relies on mel frequency cepstral coefficient features from acoustic data. The primary objective of this study is to increase fault detection performance. As well as designing an ensemble model, we utilize selective features using chi-square(chi2) that have high importance with respect to the target class. Extensive experiments were carried out to analyze the efficiency of the proposed approach. The experimental results suggest that using 60 features, 40 original features, and 20 chi2 features produces optimal results both regarding accuracy and computational complexity. A mean accuracy score of 0.99 was obtained using the proposed approach with machine learning models using the collected data. Moreover, this performance was significantly better than that of existing approaches; however, the performance of models may vary in real-world settings.

Producción Científica

Furqan Rustam mail , Abid Ishaq mail , Muhammad Shadab Alam Hashmi mail , Hafeez Ur Rehman Siddiqui mail , Luis Dzul Lopez mail luis.dzul@unini.edu.mx, Juan Castanedo Galán mail juan.castanedo@uneatlantico.es, Imran Ashraf mail ,

Rustam

<a href="/8653/1/sensors-23-06839-v2.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

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Enhancing Cricket Performance Analysis with Human Pose Estimation and Machine Learning

Cricket has a massive global following and is ranked as the second most popular sport globally, with an estimated 2.5 billion fans. Batting requires quick decisions based on ball speed, trajectory, fielder positions, etc. Recently, computer vision and machine learning techniques have gained attention as potential tools to predict cricket strokes played by batters. This study presents a cutting-edge approach to predicting batsman strokes using computer vision and machine learning. The study analyzes eight strokes: pull, cut, cover drive, straight drive, backfoot punch, on drive, flick, and sweep. The study uses the MediaPipe library to extract features from videos and several machine learning and deep learning algorithms, including random forest (RF), support vector machine, k-nearest neighbors, decision tree, linear regression, and long short-term memory to predict the strokes. The study achieves an outstanding accuracy of 99.77% using the RF algorithm, outperforming the other algorithms used in the study. The k-fold validation of the RF model is 95.0% with a standard deviation of 0.07, highlighting the potential of computer vision and machine learning techniques for predicting batsman strokes in cricket. The study’s results could help improve coaching techniques and enhance batsmen’s performance in cricket, ultimately improving the game’s overall quality.

Producción Científica

Hafeez Ur Rehman Siddiqui mail , Faizan Younas mail , Furqan Rustam mail , Emmanuel Soriano Flores mail emmanuel.soriano@uneatlantico.es, Julién Brito Ballester mail julien.brito@uneatlantico.es, Isabel de la Torre Diez mail , Sandra Dudley mail , Imran Ashraf mail ,

Siddiqui