UnincolAdherence to the Mediterranean diet, inflammatory biomarkers and cognitive status in older Italian adultsMargheritaGrassoauthorFrancescaL’EpiscopoauthorAnnamariaFidilioauthorMarco AntonioOlvera-MoreiraauthorGiuseppeToscanoauthorStefanoMuratoreauthorMargheritaDragoauthorSabrinaMussoauthorVeronicaBentivegnaauthorLucreziaCostanzoauthorMelannieToral-NoristzauthorRaynierZambrano-VillacresauthorLisandraLeón BrizuelaauthorGiuseppeLanzaauthorRaffaeleFerriauthorFilippoCaraciauthorBackground: Mild Cognitive Impairment (MCI) is viewed as a transitional stage between normal brain aging and dementia and is characterized by subtle cognitive deficits without significant impairment in daily functioning. Growing evidence supports the contribution of neuroinflammation and modifiable lifestyle factors, including diet, in the progression of cognitive decline.Aim: This study aimed to investigate the association between adherence to the Mediterranean diet, neuroinflammatory biomarkers, and MCI status in older adults.Design: Ninety-two participants were enrolled in this cross-sectional study, including 37 subjects with MCI. Dietary intake was assessed using a validated food frequency questionnaire (FFQ) and adherence to the Mediterranean diet explored through the MedDietScore. Plasma levels of TGF-β1 and TNF-α were measured by ELISA. Cognitive status was evaluated using the Mini Mental Examination (MMSE) and the Montreal Cognitive Assessment (MoCA), both adjusted for age and education. Statistical analyses included non-parametric tests, correlation analysis, and logistic regression models.Results: MCI patients showed significantly reduced plasma levels of TGF-β1 and increased TNF-α concentrations compared to other participants. After adjustment for potential confounding factors, greater adherence to the Mediterranean diet was associated with a lower likelihood of MCI in a dose–response manner (highest versus lowest adherence quartile, odds ratio: 0.07, 95% confidence interval: 0.01–0.60). Additional adjustment for inflammatory biomarkers attenuated the associations, suggesting a potential mediating role.Conclusion: Our findings showed that higher adherence to Mediterranean diet is associated with lower likelihood of being MCI. Such a relation might be, at least in part, mediated by inflammatory biomarkers. Overall, these results support the role of dietary modulation in preventive strategies against cognitive decline and progression into MCI.PsicologíaAlimentación2026-04Artículo

Para trabajos depositados por su propio autor: Al auto-archivar esta colección de ficheros y metadatos bibliográficos asociados, otorgo a Unincol el derecho para almacenarlos y ponerlos a disposición pública permanentemente de un modo gratuito y en línea. Declaro que este material es de mi propiedad intelectual y entiendo que Unincol no asume ninguna responsabilidad en caso de que se produzca una violación de derechos de propiedad al distribuir estos ficheros o metadatos. (Se insta encarecidamente a todos los autores a destacar sus derechos de autor en la página de título de su trabajo.)

Para trabajos depositados por otras personas distintas a su autor: Por la presente, declaro que la colección de ficheros y metadatos bibliográficos asociados que estoy archivando en Unincol) es de dominio público. Si este no fuese el caso, acepto totalmente la responsabilidad por cualquier infracción de derechos de autor que conlleve la distribución de estos ficheros o metadatos.

Pulsar sobre el botón de depósito indica que está de acuerdo con estos términos.