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primary topic: Fish consumption and brain structure: a comprehensive systematic review of observational studies

Fish consumption and brain structure: a comprehensive systematic review of observational studies
type: AcademicArticle
type: Article
abstract: Background Age-related structural changes in the human brain, including cortical atrophy, reductions in grey and white matter volumes, and the accumulation of small vessel–related lesions such as white matter hyperintensities (WMH) and cerebral microbleeds, represent critical biological substrates underlying cognitive decline and dementia. Fish consumption has been associated with slower cognitive decline and reduced risk of dementia, but a comprehensive evaluation of its relation with brain structures is lacking. Aims The aim of this study was to systematically review current scientific literature providing evidence of relation between fish intake and brain structures in human studies. Methods Studies indexed in two major electronic databases have been screened based on a combination of keywords and MeSH terms. Studies were eligible whether they assessed fish consumption in relation to brain structures in the adult populations. Results A total of 24 studies conducted predominantly on older adults met inclusion criteria. Most brain volume measures were obtained via magnetic resonance imaging (MRI) procedures. Higher fish consumption was associated with reduced severity of white matter hyperintensities (a biomarker of cerebral small vessel disease and white matter damage) and cerebral micro-bleed, preservation of certain brain areas volumes (i.e., hippocampus, temporal lobe and periventricle white matter) and cortical thickness of specific areas (i.e., precuneus, parietal, and cingulate grey matter), among others, compared to lower intake. Some analyses found no association and isolated findings suggested possible adverse associations that were not consistently replicated. Studies reporting null findings may underline the possible relevance of the overall diet (i.e., adherence to the Mediterranean diet). Conclusions Inclusion of fish in a healthy and balanced diet is associated with better white matter grades on MRI and slower progression of white matter hyperintensi…
date: 2026-04
is part of: Aging Clinical and Experimental Research
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Fish consumption and brain structure: a comprehensive systematic review of observational studies (Texto)
subject: Biomedicine
subject: Nutrition

Fish consumption and brain structure: a comprehensive systematic review of observational studies (Texto)
type: Document
has file: s40520-026-03363-x_reference.pdf
has part: s40520-026-03363-x_reference.pdf

Aging Clinical and Experimental Research
type: Collection
issn: 17208319

Mario Siervo
type: Person
given name: Mario
family name: Siervo

Alberto Dolci
type: Person
given name: Alberto
family name: Dolci

Lisandra León Brizuela
type: Person
given name: Lisandra
family name: León Brizuela

Evelyn Frias-Toral
type: Person
given name: Evelyn
family name: Frias-Toral

Agnieszka Micek
type: Person
given name: Agnieszka
family name: Micek

Andrea Di Mauro
type: Person
given name: Andrea
family name: Di Mauro

Giuseppe Grosso
type: Person
given name: Giuseppe
family name: Grosso

Justyna Godos
type: Person
given name: Justyna
family name: Godos

Giuseppe Caruso
type: Person
given name: Giuseppe
family name: Caruso

Michelino Di Rosa
type: Person
given name: Michelino
family name: Di Rosa

Andrea Lehoczki
type: Person
given name: Andrea
family name: Lehoczki

Zoltan Ungvari
type: Person
given name: Zoltan
family name: Ungvari

HTML Summary of #28323 Fish consumption and brain structure: a comprehensive systematic review of observational studies
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primary topic: Fish consumption and brain structure: a comprehensive systematic review of observational studies

Biomedicine
type: Concept
preferred label: Biomedicina @es

Nutrition
type: Concept
preferred label: Alimentación @es